The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Default mode network dissociation in depressive and anxiety states
Open accessAbstract
The resting state brain networks, particularly the Default Mode Network (DMN), have been found to be altered in several psychopathological conditions such as depression and anxiety. In this study we hypothesized that cortical areas of the DMN, particularly the anterior regions--medial prefrontal cortex and anterior cingulate cortex--would show an increased functional connectivity associated with both anxiety and depression. Twenty-four healthy participants were assessed using Hamilton Depression and Anxiety Rating Scales and completed a resting-state functional magnetic resonance imaging scan. Multiple regression was performed in order to identify which areas of the DMN were associated with anxiety and depression scores. We found that the functional connectivity of the anterior portions of DMN, involved in self-referential and emotional processes, was positively correlated with anxiety and depression scores, whereas posterior areas of the DMN, involved in episodic memory and perceptual processing were negatively correlated with anxiety and depression scores. The dissociation between anterior and posterior cortical midline regions, raises the possibility of a functional specialization within the DMN in terms of self-referential tasks and contributes to the understanding of the cognitive and affective alterations in depressive and anxiety states.
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“However, recent research suggests that a focus on overall DMN connectivity may be overly simplistic, and that instead, connectivity between anterior portions of the DMN may be positively correlated with anxiety and depression symptoms while connectivity between posterior nodes of the DMN may be negatively correlated with depression and anxiety symptoms (Coutinho et al., 2016).”
From Changes in functional connectivity following treatment with emotion regulation therapy (2019) · cites this paper as Coutinho et al., 2016
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Brown, O., Smith, A., Cairncross, M., Dodd, A. B., Goldfield, G. S., Gray, C., Harris, A. D., Jaworska, N., Saab, B. J., Sicard, V., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1771767
Ran, W., Shi, Q., Pan, G., Yuan, Y., 张体江, & Chen, G. (2026) · Research Square · doi:10.21203/rs.3.rs-10841458/v1
Metadata
- Authors
- Coutinho, J. F., Fernandesl, S. V., Soares, J. M., Maia, L., Gonçalves, Ó. F., & Sampaio, A.
- Affiliations
- University of Minho (PT)
- Northeastern University (US)
- Corresponding author
- Coutinho, Joana Fernandes
- Venue
- Brain Imaging and Behavior
- Published
- 2015-03-26
- Volume
- 10
- Issue
- 1
- Pages
- 147-157
- ISSN
- 1931-7557 (ISSN-L)
- 1931-7565
- OpenAlex
- W1985472839
- Cited by
- 203
- References
- 89
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 19 · 2023: 26 · 2022: 24 · 2021: 28 · 2020: 19 · 2019: 13 · 2018: 13 · 2017: 10 · 2016: 11 · 2015: 3
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Brain Imaging and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- Fundação Bial
- Programa Operacional Temático Factores de Competitividade
- Fundação para a Ciência e a Tecnologia
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- default mode network, depression, anxiety, resting-state functional connectivity, anterior cingulate cortex, medial prefrontal cortex, self-referential processing, episodic memory
- MeSH terms
- Adult, Anxiety, Brain, Brain Mapping, Depression, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Psychiatric Status Rating Scales, Regression Analysis, Rest, Young Adult
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