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Cited by 125Bariatric Surgery and OutcomesMinimally Invasive Surgical TechniquesPancreatic function and diabetes

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Severe Recurrent Hypoglycemia after Gastric Bypass Surgery

Z’graggen, Kaspar, Guweidhi, Ahmed, Steffen, Rudolf, Potoczna, Natascha, Biral, Ruggero, Walther, Frank, Komminoth, Paul, Horber, Fritz·2008·Obesity Surgery
DOI 10.1007/s11695-008-9480-4
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Abstract

Background Bariatric surgery is, at present, the most effective method to achieve major, long-term weight loss in severely obese patients. Recently, severe recurrent symptomatic hyperinsulinemic hypoglycemia was described as a consequence of gastric bypass surgery (GBS) in a small series of patients with severe obesity. Pancreatic nesidioblastosis, a hyperplasia of islet cells, was postulated to be the cause, and subtotal or total pancreatectomy was the suggested treatment. Methods We observed that severe, disabling hypoglycemia after GBS occurred only in patients with loss of restriction. Whether restoration of gastric restriction might treat severe, recurrent hypoglycemia after GBS is unknown. Results Therefore, gastric restriction was restored by surgical placement of a silastic ring (n = 8, first two patients with additional distal pancreatectomy) or an adjustable gastric band (n = 4) around the pouch in 12 consecutive patients presenting with severe hypoglycemia (blood glucose below 2.2 mM). At follow-up after restoration of gastric restriction (median follow-up 7 months, range 5 to 19 months), 11 patients demonstrated no hypoglycemic episodes, while one had recurrence of hypoglycemia and underwent distal pancreatectomy. Procedural mortality was 0% and morbidity 8.3%. Conclusion Patients suffering from severe recurrent hypoglycemia after GBS can be treated, in most cases, just by restoration of gastric restriction. Distal pancreatectomy should be considered a second-line…

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Crossref · 10.1007/s11695-008-9480-4

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37 of 37 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. CDC. State-specific prevalence of obesity among adults—United States, 2005. MMWR Morb Mortal Wkly Rep. 2006;55(36):985–8.

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Metadata

Authors
Z’graggen, K., Guweidhi, A., Steffen, R., Potoczna, N., Biral, R., Walther, F., Komminoth, P., & Horber, F.
Affiliations
Triemli Hospital (CH)
Corresponding author
Horber, Fritz
ORCID
Venue
Obesity Surgery
Publisher
Springer Science and Business Media LLC
Published
2008-04-26
Volume
18
Issue
8
Pages
981-988
ISSN
  • 0960-8923 (ISSN-L)
  • 1708-0428
DOI
10.1007/s11695-008-9480-4
OpenAlex
W2055803430
Cited by
125
References
37
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 10 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 6 · 2018: 1 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 11 · 2012: 5
FWCI
11.96
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Obesity Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
recurrent hypoglycemia, gastric bypass
MeSH terms
Adult, Dumping Syndrome, Female, Follow-Up Studies, Humans, Hypoglycemia, Male, Middle Aged, Obesity, Morbid, Pancreatectomy, Laparoscopy, Recurrence, Severity of Illness Index, Gastric Bypass

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