Effect of surgically induced weight loss on biomarkers of endothelial dysfunction: a systematic review and meta-analysis
Abstract
Background This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin.Methods PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies.Results A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = - 58.91; 95%CI (confidence interval), - 77.10 to - 40.72; P = ˂ 0.001), ICAM-1 (WMD = - 36.58; 95%CI, - 49.65 to - 23.52; P = ˂ 0.001), and E-selectin (WMD = - 11.22; 95%CI, - 14.43 to - 8.01; P < 0.001), but had no significant effect on VCAM-1.Conclusion Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several reviews of bariatric surgery found that E-selectin and sICAM-1 decreased after surgery, although this was not always consistent for sICAM-1.
“Several reviews of bariatric surgery found that E-selectin and sICAM-1 decreased after surgery, 15,39 although this was not always consistent for sICAM-1. 40”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [39]
Endothelial markers such as sICAM-1 and E-selectin declined comparably across both modalities, suggesting shared vascular benefits.
“Endothelial markers such as sICAM-1 and Eselectin declined comparably across both modalities, suggesting shared vascular benefits. 39”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [39]
The citation lists haven’t been fetched yet
References 55 · Cited by 12
- Authors
- Seyyedi, J., & Alizadeh, S.
- Affiliations
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Alizadeh, Shahab
- Venue
- Obesity Surgery
- Published
- 2020-06-01
- Volume
- 30
- Issue
- 9
- Pages
- 3549-3560
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W3030971901
- Cited by
- 12
- References
- 55
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- bariatric surgery
- MeSH terms
- Endothelium, Vascular, Humans, Obesity, Morbid, Biomarkers, Weight Loss, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, E-Selectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
