Are the Changes in Gastrointestinal Hormone Secretion Necessary for the Success of Bariatric Surgery? A Critical Review of the Literature
Abstract
Ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) are involved in energy balance regulation and glucose homeostasis. Obesity is characterized by lower fasting levels and blunted postprandial responses of ghrelin, GLP-1, and possibly PYY. Both Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) have been shown to increase postprandial GLP-1 and PYY levels. Human studies have shown that enhanced postprandial GLP-1 and PYY release are associated with favorable weight loss outcomes after RYGB. However, studies in knockout mice have shown that GI hormones are not required for the primary metabolic effects of bariatric surgery. Here, we summarize the complex interaction between obesity, bariatric surgery, and GI hormones in order to determine the exact role of GI hormones in the success of bariatric surgery.
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Some studies indicate that the hormonal changes after bariatric surgery might wane with time, which may be associated with the development of weight regain.
“Some studies indicate that the observed hormonal changes after bariatric surgery might wane with time [36], which may be associated with the development of weight regain.”
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References 68 · Cited by 30
- Authors
- Lampropoulos, C., Alexandrides, T., Tsochatzis, S., Kehagias, D., & Kehagias, I.
- Affiliations
- General University Hospital of Patras (GR)
- Corresponding author
- Lampropoulos, Charalampos
- Venue
- Obesity Surgery
- Published
- 2021-07-25
- Volume
- 31
- Issue
- 10
- Pages
- 4575-4584
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W3185960785
- Cited by
- 30
- References
- 68
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 10 · 2023: 7 · 2022: 2
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- gastrointestinal hormones, bariatric surgery
- MeSH terms
- Animals, Gastrectomy, Gastrointestinal Hormones, Obesity, Morbid, Gastric Bypass, Peptide YY, Bariatric Surgery, Mice
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