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Cited by 96

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Association of ceramides in human plasma with risk factors of atherosclerosis

Ichi, Ikuyo, Nakahara, Kayoko, Miyashita, Yavoi, Hidaka, Atsuko, Kutsukake, Sahoko, Inoue, Kana, Maruyama, Taro, Miwa, Yoshikazu, Harada‐Shiba, Mariko, Tsushima, Motoo, Kojo, Shosuke, Kisei Cohort Study Group·2006·Lipids
DOI 10.1007/s11745-006-5041-6
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Abstract

Atherosclerosis is a multifactorial disorder. Recent studies indicate that the plasma level of sphingomyelin, which yields ceramide, correlates with the risk of coronary heart disease. Therefore, ceramide, a well‐known lipid causing apoptosis in various cell types, may contribute to atherogenesis. We examined the relationship between ceramide concentration and risk factors of atherosclerosis in normal human plasma using electrospray tandem mass spectrometry (LC‐MS/MS). Major ceramides in human plasma were C24∶0 and C24∶1. The ceramide concentration showed a significant positive correlation with total cholesterol (TC) and triglycerides (TG). In addition, plasma ceramide level increased drastically at a high level of LDL cholesterol (more than 170 mg/dL). Our previous studies demonstrated that the sum of fragmented and conjugated apolipoprotein B‐100 proteins (B‐ox), which were products of a radical reaction of LDL as well as plasma, was a reliable index of atherosclerosis. B‐ox showed a significant positive correlation with the plasma ceramide level. Based on these results, we propose that the ceramide level in human plasma is a risk factor at the early stages of atherosclerosis.

Overview

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Registry

Crossref · 10.1007/s11745-006-5041-6

Cites

49 of 49 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 1

  1. 10.1080/713803618 · DOI

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Metadata

Authors
Ichi, I., Nakahara, K., Miyashita, Y., Hidaka, A., Kutsukake, S., Inoue, K., Maruyama, T., Miwa, Y., Harada‐Shiba, M., Tsushima, M., Kojo, S., & Kisei Cohort Study Group
Affiliations
  • Department of Food Science and Nutrition Nara Women's University Nara 630‐8506 Japan
  • Social Insurance Saitama Chuo Hospital Kitaurawa, Saitama 336‐0002 Japan
  • Department of Clinical Pharmacology, Faculty of Medical Sciences Kyushu University Fukuoka 812‐8582 Japan
  • Department of Bioscience National Cardiovascular Center Research Institute Suita Osaka 565‐8565 Japan
  • Department of Geriatric Medicine of Atami Hospital International University of Health and Welfare Atami Shizuoka 413‐0012 Japan
Venue
Lipids
Publisher
Wiley
Published
2006-09
Volume
41
Issue
9
Pages
859-863
ISSN
  • 0024-4201
  • 1558-9307
DOI
10.1007/s11745-006-5041-6
Cited by
96
References
49
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Association of ceramides in human plasma with risk factors of atherosclerosis. https://app.cochat.ai/papers/10.1007/s11745-006-5041-6
The paper
Ichi, I., Nakahara, K., Miyashita, Y., Hidaka, A., Kutsukake, S., Inoue, K., Maruyama, T., Miwa, Y., Harada‐Shiba, M., Tsushima, M., Kojo, S., & Kisei Cohort Study Group. (2006). Association of ceramides in human plasma with risk factors of atherosclerosis. Lipids. https://doi.org/10.1007/s11745-006-5041-6

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.