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Cited by 27Lipid metabolism and disordersLipoproteins and Cardiovascular HealthNutrition, Genetics, and Disease

Genetic determinants of plasma triglycerides: impact of rare and common mutations

Talmud, Philippa J.·2001·Current Atherosclerosis Reports
DOI 10.1007/s11883-001-0061-4
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Abstract

Raised plasma triglyceride (TG) levels are an independent risk factor for coronary artery disease (CAD), and thus understanding the genetic and environmental determinants of TG levels are of major importance. TG metabolism is a process for delivering free fatty acids for energy storage or b-oxidation, and involves a number of different hydrolytic enzymes and apolipoproteins (apo). The genes encoding these proteins are, therefore, candidates for determining plasma TGs. Although rare mutations in lipoprotein lipase (LPL), the major TG-hydrolyzing enzyme, and apo CII (APOC2), its essential activator, result in extremely high plasma TG levels, their low frequency means they have little impact upon TG levels in the general population. Common mutations in LPL, apo CIII (APOC3), and apo E (APOE) have the strongest effect on plasma TG levels at the population level. In addition, environmental factors such as diet, obesity, and smoking interact with genetic determinants of TG to produce a modulating high-risk environment.

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Authors
Talmud, P. J.
Affiliations
The Royal Free Hospital (GB)
Corresponding author
Talmud, Philippa J.
ORCID
Talmud, Philippa J.
Venue
Current Atherosclerosis Reports
Publisher
Springer Science and Business Media LLC
Published
2001-05
Volume
3
Issue
3
Pages
191-199
ISSN
  • 1523-3804 (ISSN-L)
  • 1534-6242
DOI
10.1007/s11883-001-0061-4
OpenAlex
W1996611209
Cited by
27
References
0
Citations by year
2023: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 1
FWCI
0.58
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Atherosclerosis Reports (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
plasma triglycerides, genetic factors, lipoprotein lipase, APOC2, apolipoprotein C-III, apolipoprotein E, triglyceride metabolism, apolipoproteins, coronary artery disease risk, gene-environment interaction, obesity, diet, smoking
MeSH terms
Animals, Humans, Mutation, Triglycerides

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