The role of inflammation in the pathogenesis of heart failure
Abstract
Heart failure is not a simple defect in the pumping function of cardiac muscle, but rather a complex systemic inflammatory disease affecting many organ systems. Recognition of this fact has led to new therapeutic interventions such as angiotensin-converting enzyme inhibitors and beta-blockers, which have a significant impact on the quality of life and survival of patients with heart failure. During the course of heart failure, the steps involved in the activation of inflammation are now better understood. As a result, new therapies will develop that block, modify, or prevent these inflammatory changes, and supplement our armamentarium for providing better and longer lives for patients.
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An inflammatory state is both a causative factor in inducing MI and a primary constituent of the response to MI.
“and an inflammatory state is both a causative factor in inducing MI and a primary constituent of the response to MI (210, 341, 385).”
From Cardiac remodeling in obesity (2008) · cites this paper as [210]
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References 21 · Cited by 18
- Authors
- Lisman, K. A., Stetson, S. J., Koerner, M. M., Farmer, J. A., & Torre-Amione, G.
- Affiliations
- Baylor College of Medicine (US)
- ORCID
- Stetson, Sonny J.
- Venue
- Current Cardiology Reports
- Published
- 2002-05
- Volume
- 4
- Issue
- 3
- Pages
- 200-205
- ISSN
- 1523-3782 (ISSN-L)
- 1534-3170
- OpenAlex
- W2092565004
- Cited by
- 18
- References
- 21
- Citations by year
- 2019: 1 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Cardiology Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- heart failure, inflammation, pathogenesis, systemic inflammatory disease, ACE inhibitors, beta-blockers, anti-inflammatory therapy, inflammatory activation
- MeSH terms
- Adrenergic beta-Antagonists, Algorithms, Angiotensin-Converting Enzyme Inhibitors, Clinical Trials as Topic, Heart Failure, Humans, Inflammation, Interleukin-1, Quality of Life, Tumor Necrosis Factor-alpha, Interleukin-6, Transforming Growth Factor beta
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