Far from the eyes, close to the heart: dysbiosis of gut microbiota and cardiovascular consequences
Open accessAbstract
These days, the gut microbiota is universally recognized as an active organ that can modulate the overall host metabolism by promoting multiple functions, from digestion to the systemic maintenance of overall host physiology. Dysbiosis, the alteration of the complex ecologic system of gut microbes, is associated with and causally responsible for multiple types of pathologies. Among the latters, metabolic diseases such as type 2 diabetes and obesity are each distinguishable by a unique gut microbiota profile. Interestingly, the specific microbiota typically found in the blood of diabetic patients also has been observed at the level of atherosclerotic plaque. Here, we report evidence from the literature, as well as a few controversial reports, regarding the putative role of gut microbiota dysbiosis-induced cardiovascular diseases, such as atherosclerosis, which are common comorbidities of metabolic dysfunction.
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Numerous facets of GI microbial community composition and metabolism have been associated with various disease states, including CVD, obesity, diabetes, and features of metabolic syndrome.
“Numerous facets of GI microbial community composition and metabolism have been associated with various disease states, including CVD, obesity, diabetes, and features of metabolic syndrome[274,310–313].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [312]
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References 62 · Cited by 93
- Authors
- Serino, M., Blasco-Baque, V., Nicolas, S., & Burcelin, R.
- Affiliations
- Université Toulouse III - Paul Sabatier (FR)
- Venue
- Current Cardiology Reports
- Published
- 2014-10-11
- Volume
- 16
- Issue
- 11
- Pages
- 540-540
- ISSN
- 1523-3782 (ISSN-L)
- 1534-3170
- PMC
- PMC4194023
- OpenAlex
- W1986227075
- Cited by
- 93
- References
- 62
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 12 · 2018: 5 · 2017: 13 · 2016: 14 · 2015: 5
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Cardiology Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Société Francophone du Diabète
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- gut microbiota, dysbiosis, cardiovascular disease, atherosclerosis, type 2 diabetes, obesity, metabolic dysfunction, atherosclerotic plaque, blood microbiota, host metabolism
- MeSH terms
- Animals, Disease Models, Animal, Humans, Immunity, Innate, Inflammation, Periodontitis, Evidence-Based Medicine, Probiotics, Gastrointestinal Tract, Atherosclerosis, Mice, Rats, Microbiota, Dysbiosis
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