Recovery of endocrine function after islet and pancreas transplantation
Open accessAbstract
Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transplantation of isolated islets and a whole pancreas can restore β-cell secretory capacity, improve glucose counter-regulation, and return hypoglycemia awareness, thus alleviating severe hypoglycemia. The transplantation of islets may require more than one donor pancreas, and the recovery of endocrine function for now appears more durable with a whole pancreas; however, islet transplantation outcomes are steadily improving. Because not all patients with T1D experiencing severe hypoglycemia are candidates to receive a whole pancreas, and since not all pancreata are technically suitable for whole organ transplantation, islet and pancreas transplantation are evolving as complementary approaches for the recovery of endocrine function in patients with the most problematic T1D.
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Islet cell transplantation reduces hypoglycemia and restores glucose counter-regulation.
“Islet cell transplantation, which has been shown to reduce hypoglycemia (48) and restore glucose counter-regulation (49), should be considered for people with type 1 diabetes who experience recurrent severe hypoglycemia (50)”
From Hypoglycemia (2018) · cites this paper as [49]
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References 102 · Cited by 49
- Authors
- Rickels, M. R.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Rickels, Michael R.
- ORCID
- Rickels, Michael R.
- Venue
- Current Diabetes Reports
- Published
- 2012-07-05
- Volume
- 12
- Issue
- 5
- Pages
- 587-596
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- PMC
- PMC3432697
- OpenAlex
- W2069128606
- Cited by
- 49
- References
- 102
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 3 · 2015: 3 · 2013: 9 · 2012: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01dk091331-10)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK-091331, U01DK070430)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- type 1 diabetes, islet transplantation, pancreas transplantation, insulin secretion, hypoglycemia unawareness, severe hypoglycemia, C-peptide, beta-cell function
- MeSH terms
- Diabetes Mellitus, Type 1, Humans, Immunosuppressive Agents, Pancreas Transplantation, Islets of Langerhans Transplantation
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