Cardiometabolic Risk in PCOS: More than a Reproductive Disorder
Open accessAbstract
Purpose of review Polycystic ovary syndrome (PCOS) is diagnosed by its characteristic reproductive features. However, PCOS is also associated with metabolic abnormalities, including insulin resistance and β-cell dysfunction. The severity of these abnormalities varies according to the reproductive phenotype, with the so-called NIH or classic phenotype conferring the greatest metabolic risk. The increased risk for type 2 diabetes (T2D) is well established among affected women with the NIH phenotype, but whether PCOS also confers an increased risk for cardiovascular events remains unknown.Recent findings Recent studies in daughters of affected women have found evidence for pancreatic β-cell dysfunction prior to menarche. Further, genetic analyses have provided evidence that metabolic abnormalities such as obesity and insulin resistance contribute to the pathogenesis of PCOS. PCOS increases the risk for T2D. However, the risk for cardiovascular disease has not been quantified, and prospective, longitudinal studies are still critically needed.
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Women with PCOS have a higher cardiometabolic risk compared with women without ovarian problems.
“Women with PCOS have a higher cardiometabolic risk compared with women without ovarian problems [11].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [11]
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References 132 · Cited by 65
Research works printed but not linked: 3
- [11]Polycystic ovary syndrome Dunaif Andrea Boston Blackwell Scientific Publications St. Louis, Mo Distributors, USA and Canada, Mosby-Year Book 1992
- [60]Ehrmann DA Barnes RB Rosenfield RL Cavaghan MK Imperial J Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome Diabetes Care 1999 22 1 141 6 10333916
- [98]Coviello AD Legro RS Dunaif A Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance J Clin Endocrinol Metab 2006 91 2 492 7 10.1210/jc.2005-1666 16249280 · DOI
- Authors
- Torchen, L. C.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Torchen, Laura C.
- ORCID
- Torchen, Laura C.
- Venue
- Current Diabetes Reports
- Published
- 2017-11-11
- Volume
- 17
- Issue
- 12
- Pages
- 137-137
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- PMC
- PMC5823507
- OpenAlex
- W2767757583
- Cited by
- 65
- References
- 132
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 14 · 2020: 8 · 2019: 6 · 2018: 6
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD090274)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Keywords
- polycystic ovary syndrome, cardiometabolic risk, insulin resistance, beta-cell dysfunction, type 2 diabetes risk, cardiovascular risk, reproductive phenotypes, obesity, genetic susceptibility
- MeSH terms
- Cardiovascular Diseases, Female, Humans, Insulin Resistance, Phenotype, Polycystic Ovary Syndrome, Risk Factors, Metabolic Syndrome
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