The Gut Microbiome as a Target for the Treatment of Type 2 Diabetes
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PURPOSE OF REVIEW: The objective of this review is to critically assess the contributing role of the gut microbiota in human obesity and type 2 diabetes (T2D). RECENT FINDINGS: Experiments in animal and human studies have produced growing evidence for the causality of the gut microbiome in developing obesity and T2D. The introduction of high-throughput sequencing technologies has provided novel insight into the interpersonal differences in microbiome composition and function. The intestinal microbiota is known to be associated with metabolic syndrome and related comorbidities. Associated diseases including obesity, T2D, and fatty liver disease (NAFLD/NASH) all seem to be linked to altered microbial composition; however, causality has not been proven yet. Elucidating the potential causal and personalized role of the human gut microbiota in obesity and T2D is highly prioritized.
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Individuals with obesity may have decreased bacterial diversity, and gut microbial dysbiosis is associated with metabolic disorders such as type 2 diabetes mellitus.
“Individuals with obesity may have decreased bacterial diversity, and gut microbial dysbiosis is associated with metabolic disorders such as T2DM101.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [101]
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References 140 · Cited by 124
Research works printed but not linked: 2
- [50]Falony G Population-level analysis of gut microbiome variation Science. 2016 352 6285 560 564 27126039
- [106]Kootte RS, Nieuwdorp M. [In press]. JAHA. 2018(In Press).
- Authors
- Aydin, Ö., Nieuwdorp, M., & Gerdes, V.
- Affiliations
- Slotervaartziekenhuis (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Gerdes, Victor
- Venue
- Current Diabetes Reports
- Published
- 2018-06-21
- Volume
- 18
- Issue
- 8
- Pages
- 55-55
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- PMC
- PMC6013535
- OpenAlex
- W2808733478
- Cited by
- 124
- References
- 140
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 15 · 2023: 16 · 2022: 13 · 2021: 28 · 2020: 22 · 2019: 14 · 2018: 3
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Diabetes Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, cc-by)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Academic Medical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, type 2 diabetes, obesity, metabolic syndrome, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, microbiome-targeted therapy, personalized medicine
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diabetes Mellitus, Type 2, Fatty Acids, Humans, Insulin Resistance, Metabolic Syndrome, Lipid Metabolism
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