Epidemiology and natural history of recovery of left ventricular function in recent onset dilated cardiomyopathies
Open accessAbstract
Although the long term prognosis of patients with dilated cardiomyopathy (DCM) remains poor, approximately 25 % of DCM patients with recent onset of heart failure (< 6 months) have a relatively benign clinical course with a spontaneously improvement in symptoms and partial, or in some cases complete, recovery of left ventricular (LV) function. Despite the longstanding recognition of the clinical phenomenon of LV recovery, relatively little attention has been paid to the etiology and natural history of this important group of DCM patients. Accordingly, in the present review we will focus on the epidemiology and natural history of recent onset DCM in patients who undergo spontaneous resolution of symptoms that is accompanied by recovery of LV function.
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MI and ischemic cardiomyopathy are among the leading causes of heart failure, associated morbidity, and death worldwide and continue to impose staggering financial burden on healthcare systems.
“Despite advancements in clinical management, MI and ischemic cardiomyopathy are among the leading causes of heart failure, associated morbidity, and death worldwide 3,4 and continue to impose staggering financial burden on healthcare systems 3,5-8 .”
From Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure (2022) · cites this paper as [7]
The Epidemiology of LV Recovery section mentions ischemic heart failure only in discussing recovery of ventricular function; it does not describe MI or ischemic cardiomyopathy as leading causes of heart failure, morbidity, or death. Searches for MI, ischemic cardiomyopathy, worldwide burden, and healthcare costs found no passage addressing those claims. (LLM, conf=0.74)
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References 70 · Cited by 76
Research works printed but not linked: 1
- Mann DL Barger PM Burkhoff D Myocardial recovery: myth, magic or molecular target? J Amer Coll Cardiol 2012 60 2465 2472 Recent article that addresses the biology of LV recovery and reverse remodeling and that introduces the concept that end organ damage prevents restoration of LV function. 23158527 PMC3522780
- Authors
- Givertz, M. M., & Mann, D. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Washington University in St. Louis (US)
- Corresponding author
- Mann, Douglas L.
- Venue
- Current Heart Failure Reports
- Published
- 2013-09-08
- Volume
- 10
- Issue
- 4
- Pages
- 321-330
- ISSN
- 1546-9530 (ISSN-L)
- 1546-9549
- PMC
- PMC3823811
- OpenAlex
- W1983112986
- Cited by
- 76
- References
- 70
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 1
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Heart Failure Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL111094, R01HL089543, R01 HL89543)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- dilated cardiomyopathy, left ventricular function recovery, natural history (disease), heart failure, prognosis, epidemiology
- MeSH terms
- Cardiomyopathy, Dilated, Humans, Myocarditis, Prognosis, Remission, Spontaneous, Ventricular Function, Left, Systemic Inflammatory Response Syndrome, Recovery of Function, Cardiotoxins
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