Dietary Nitrate and Skeletal Muscle Contractile Function in Heart Failure
Open accessAbstract
Heart failure (HF) patients suffer from exercise intolerance that diminishes their ability to perform normal activities of daily living and hence compromises their quality of life. This is due largely to detrimental changes in skeletal muscle mass, structure, metabolism, and function. This includes an impairment of muscle contractile performance, i.e., a decline in the maximal force, speed, and power of muscle shortening. Although numerous mechanisms underlie this reduction in contractility, one contributing factor may be a decrease in nitric oxide (NO) bioavailability. Consistent with this, recent data demonstrate that acute ingestion of NO3 (-)-rich beetroot juice, a source of NO via the NO synthase-independent enterosalivary pathway, markedly increases maximal muscle speed and power in HF patients. This review discusses the role of muscle contractile dysfunction in the exercise intolerance characteristic of HF, and the evidence that dietary NO3 (-) supplementation may represent a novel and simple therapy for this currently underappreciated problem.
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In heart failure and cardiomyopathy, dietary nitrate improves left ventricular function in mice and overall cardiac contractility and exercise performance in humans.
“Additionally, in the setting of heart failure and cardiomyopathy, dietary nitrate improves left ventricular function in mice[133] and overall cardiac contractility and exercise performance in humans[134–137]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [135]
Clinically, nitrate supplementation improves exercise performance in patients with heart failure and HFpEF.
“improved exercise performance in patients with heart failure and HFpEF[135,137,151].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [135]
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References 86 · Cited by 20
Research works printed but not linked: 1
- [42]Szentesi P Bekedam MA van Beek-Harmsen BJ van der Laarse WJ Zaremba R Boonstra A Visser FC Stienen GJ Depression of force production and ATPase activity in different types of human skeletal muscle fibers from patients with chronic heart failure J Appl Physiol 2005 99 2189 2195 16051711
- Authors
- Coggan, A. R., & Peterson, L. R.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Coggan, Andrew R.
- Venue
- Current Heart Failure Reports
- Published
- 2016-06-06
- Volume
- 13
- Issue
- 4
- Pages
- 158-165
- ISSN
- 1546-9530 (ISSN-L)
- 1546-9549
- PMC
- PMC6092014
- OpenAlex
- W2412493654
- Cited by
- 20
- References
- 86
- Citations by year
- 2026: 3 · 2025: 1 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Heart Failure Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000448)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- heart failure, dietary nitrate, skeletal muscle contractile function, exercise intolerance, nitric oxide bioavailability, beetroot juice, nitrate supplementation, muscle power, muscle speed, exercise capacity
- MeSH terms
- Fruit and Vegetable Juices, Activities of Daily Living, Biological Availability, Heart Failure, Humans, Muscle Contraction, Nitrates, Nitric Oxide, Quality of Life, Muscle, Skeletal, Dietary Supplements, Beta vulgaris
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