Gut Microbiome and Multiple Sclerosis
Abstract
The commensal flora that lives in the human gut is a unique ecosystem that has evolved over millennia with human beings. The importance of the microbiota in various bodily functions is gradually becoming more apparent. Besides the gut microbiome playing a role in bowel-related disorders, a role in metabolic and autoimmune disorders is becoming clearer. The gut bacteria play a role in educating the immune system and hence may be a player in the development of multiple sclerosis. We examine the different sources of information linking the gut microbiota to multiple sclerosis and examine the future avenues for utilizing the knowledge of the gut microbiome to potentially treat and prevent multiple sclerosis.
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Multiple sclerosis patients with active disease have an altered microbiota compared to patients in the remission phase, who have a microbiota more similar to healthy controls.
“Interestingly, even MS patients with active disease have an altered microbiota compared to patients in the remission phase, which in turn have a microbiota more similar to healthy controls (25, 134–138).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [136]
Abnormal bile acid metabolism has been described in neurological diseases, suggesting a role for transformation of bile acids by gut microbiota in Alzheimer's disease development/progression and cognitive decline.
“Recently, abnormal bile acid metabolism was described in neurological diseases, suggesting a role for the transformation of bile acids by gut microbiota as a factor in Alzheimer's disease development/progression and cognitive decline (409, 410).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [410]
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References 68 · Cited by 129
- Authors
- Bhargava, P., & Mowry, E. M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Mowry, Ellen M.
- Venue
- Current Neurology and Neuroscience Reports
- Published
- 2014-09-10
- Volume
- 14
- Issue
- 10
- Pages
- 492-492
- ISSN
- 1528-4042 (ISSN-L)
- 1534-6293
- OpenAlex
- W2070304795
- Cited by
- 129
- References
- 68
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 12 · 2019: 20 · 2018: 11 · 2017: 18 · 2016: 11 · 2015: 12 · 2014: 2
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Neurology and Neuroscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- gut microbiota, multiple sclerosis, autoimmune disease, commensal bacteria, metabolic disorders, bowel disorders, microbiota-based therapy, disease prevention
- MeSH terms
- Disease Susceptibility, Humans, Multiple Sclerosis, Gastrointestinal Tract, Microbiota
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