Marrow adiposity and hematopoiesis in aging and obesity: exercise as an intervention
Open accessAbstract
Purpose of review Changes in the bone marrow microenvironment, which accompany aging and obesity, including increased marrow adiposity, can compromise hematopoiesis. Here, we review deleterious shifts in molecular, cellular, and tissue activity and consider the potential of exercise to slow degenerative changes associated with aging and obesity.Recent findings While bone marrow hematopoietic stem cells (HSC) are increased in frequency and myeloid-biased with age, the effect of obesity on HSC proliferation and differentiation remains controversial. HSC from both aged and obese environment have reduced hematopoietic reconstitution capacity following bone marrow transplant. Increased marrow adiposity affects HSC function, causing upregulation of myelopoiesis and downregulation of lymphopoiesis. Exercise, in contrast, can reduce marrow adiposity and restore hematopoiesis. The impact of marrow adiposity on hematopoiesis is determined mainly through correlations. Mechanistic studies are needed to determine a causative relationship between marrow adiposity and declines in hematopoiesis, which could aid in developing treatments for conditions that arise from disruptions in the marrow microenvironment.
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Physical activity is necessary to lose weight and improve muscle strength, which is beneficial to ameliorate the state of sarcopenic obesity.
“Numerous studies have proven that physical activity is necessary to lose weight and improve muscle strength, which is beneficial to ameliorate the state of SO (16, 17).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [16]
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References 105 · Cited by 39
Research works printed but not linked: 1
- [89]Styner M Pagnotti GM McGrath C Wu X Sen B Uzer G Exercise Decreases Marrow Adipose Tissue Through ss-Oxidation in Obese Running Mice J Bone Miner Res 2017 10.1002/jbmr.3159 PMC5550355 28436105 · DOI
- Authors
- Patel, V. S., Ete Chan, M., Rubin, J., & Rubin, C. T.
- Affiliations
- Stony Brook University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Rubin, Clinton T.
- Venue
- Current Osteoporosis Reports
- Published
- 2018-02-23
- Volume
- 16
- Issue
- 2
- Pages
- 105-115
- ISSN
- 1544-1873 (ISSN-L)
- 1544-2241
- PMC
- PMC5866776
- OpenAlex
- W2791215577
- Cited by
- 39
- References
- 105
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 1
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Osteoporosis Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (U01HL127522)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR066616, R01AR043498)
- National Institute of Biomedical Imaging and Bioengineering (R01EB014351)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- bone marrow adiposity, hematopoiesis, aging, obesity, physical activity, hematopoietic stem cells, bone marrow microenvironment, myelopoiesis, lymphocyte development, hematopoietic recovery, bone marrow transplantation
- MeSH terms
- Aging, Bone Marrow, Cell Differentiation, Hematopoiesis, Hematopoietic Stem Cells, Humans, Obesity, Exercise, Lymphopoiesis, Myelopoiesis, Cell Proliferation, Adiposity
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