The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Idiopathic Intracranial Hypertension After Abrupt Cessation of Medication: A Case Report of Abrupt Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Cessation and Review of the Literature
Open accessAbstract
Purpose of Review: The purpose of this review is two-fold: (1) to discuss a case report of idiopathic intracranial hypertension (IIH) after abrupt cessation of a glucagon-like peptide-1 (GLP-1) receptor agonist with resultant rapid weight gain and (2) to review the literature regarding the potential role of GLP-1 receptor agonists in the treatment of IIH as well as potential pitfalls. Recent Findings: GLP-1 receptor agonists have become widely used to treat obesity. Obesity is a known risk factor for the development of IIH, though the precise pathophysiology is unclear. GLP-1 receptor agonists may help treat IIH by promoting weight loss, lipolysis of adipose tissue, and potentially decreasing the secretion of CSF, as was seen in rat models. Abrupt cessation of GLP-1 receptor agonists can result in regaining lost weight rapidly. In the case that we present, the patient stopped duraglutide abruptly due to lack of insurance coverage and regained the weight she had lost within a month. She subsequently developed IIH. Summary: GLP-1 receptor agonists have the potential to help treat IIH; however, this class of medication needs to be used carefully, as cessation of the medication and resultant rapid weight gain can result in IIH.
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![Fig. 1 Diagnostic criteria for idiopathic intracranial hypertension (IIH), per “The International Classification of Headache Disorders, Third Edition (ICHD-3) [1]”](/paper-figures/8ce2dc24ba9d440eb7d5821cb1e52025/idiopathic-intracranial-hypertension-after-abrupt-cessation-of-medication-a-case-figure-1.jpg)
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“Recent evidence suggests that abrupt weight regain after discontinuation of GLP-1 receptor agonists may precipitate complications such as idiopathic intracranial hypertension.42”
From Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis (2025) · cites this paper as [42]
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Arnold, M. (2018) · Cephalalgia · doi:10.1177/0333102417738202 · Cited by 11,090
Sinclair, A. J., Burdon, M., Nightingale, P., Ball, A. K., Good, P. A., Matthews, T. D., Jacks, A. S., Lawden, M., Clarke, C. E., Stewart, P. M., et al. (2010) · BMJ · doi:10.1136/bmj.c2701 · Cited by 358
Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management
Mollan, S. P., Ali, F., Hassan‐Smith, G., Botfield, H. F., Friedman, D. I., & Sinclair, A. J. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-311302 · Cited by 258
Mollan, S. P., Mitchell, J., Ottridge, R. S., Aguiar, M., Yiangou, A., Alimajstorovic, Z., Cartwright, D. M., Grech, O., Lavery, G. G., Westgate, C. S. J., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.0659 · Cited by 173
Botfield, H. F., Uldall, M., Westgate, C. S. J., Mitchell, J., Hagen, S. M., Gonzalez, A. M., Hodson, D. J., Jensen, R., & Sinclair, A. J. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan0972 · Cited by 169
Weight gain and recurrence in idiopathic intracranial hypertension
Ko, M. W., Chang, S.-H., Ridha, M. A., Ney, J. J., Ali, T. F., Friedman, D. I., Mejico, L. J., Volpe, N. J., Galetta, S. L., Balcer, L. J., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e3182190f51 · Cited by 156
Adderley, N. J., Subramanian, A., Nirantharakumar, K., Yiangou, A., Gokhale, K. M., Mollan, S. P., & Sinclair, A. J. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1812 · Cited by 154
Hornby, C., Mollan, S. P., Botfield, H. F., O’Reilly, M., & Sinclair, A. J. (2018) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000684 · Cited by 124
Hornby, C., Botfield, H. F., O’Reilly, M., Westgate, C. S. J., Mitchell, J., Mollan, S. P., Manolopoulos, K. N., Tomlinson, J., & Sinclair, A. J. (2017) · Neuro-Ophthalmology · doi:10.1080/01658107.2017.1334218 · Cited by 63
The Potentially Modifiable Risk Factor in Idiopathic Intracranial Hypertension
Mollan, S. P., Tahrani, A. A., & Sinclair, A. J. (2021) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000001063 · Cited by 60
Cited by
Tzang, C.-C., Wu, P.-H., Luo, C.-A., Chen, Z.-T., Lee, Y.-T., Huang, E. S., Kang, Y.-F., Lin, W.-C., Tzang, B.-S., & Hsu, T.-C. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103680 · Cited by 73
“42 Dual GIP/GLP-1 receptor agonists have likewise shown potential benefits in IIH management, possibly through reduced CSF secretion and intracranial pressure.”
Halloum, W., Dughem, Y. A., Beier, D., & Pellesi, L. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01821-3 · Cited by 63
Advances in GLP-1 receptor agonists for pain treatment and their future potential
He, Y., Xu, B., Zhang, M., Chen, D., Wu, S., Gao, J., Liu, Y., Zhang, Z., Kuang, J., & Fang, Q. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-01979-4 · Cited by 44
O’Leary, S., Price, A., Camarillo‐Rodriguez, L., Costa, M. L., Karas, P. J., Young, C. C., Srinivasan, V. M., & Kan, P. T. M. (2025) · Journal of neurosurgery · doi:10.3171/2025.1.jns242357 · Cited by 19
Glucagon-like peptide-1 receptor agonists and the eye
Zhang, D. L., & Finn, A. P. (2025) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000001137 · Cited by 13
Metadata
- Authors
- Heckel, B.
- Affiliations
- Thomas Jefferson University (US)
- Corresponding author
- Heckel, Brittany
- Venue
- Current Pain and Headache Reports
- Published
- 2024-04-04
- Volume
- 28
- Issue
- 6
- Pages
- 453-456
- ISSN
- 1531-3433 (ISSN-L)
- 1534-3081
- PMC
- PMC11156736
- OpenAlex
- W4393935459
- Cited by
- 13
- References
- 13
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 1
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Current Pain and Headache Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The Medicine Forum (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Keywords
- idiopathic intracranial hypertension, GLP-1 receptor agonists, weight regain, obesity, weight loss, obesity as risk factor, cerebrospinal fluid production, insurance coverage
- MeSH terms
- Glucagon-Like Peptide-1 Receptor Agonists, Adult, Female, Humans, Obesity, Pseudotumor Cerebri, Weight Gain
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- CoChat. (2026). Citation check: Idiopathic Intracranial Hypertension After Abrupt Cessation of Medication: A Case Report of Abrupt Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Cessation and Review of the Literature. https://app.cochat.ai/papers/10.1007/s11916-024-01215-9
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- Heckel, B. (2024). Idiopathic Intracranial Hypertension After Abrupt Cessation of Medication: A Case Report of Abrupt Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Cessation and Review of the Literature. Current Pain and Headache Reports. https://doi.org/10.1007/s11916-024-01215-9
