Treating Circadian Rhythm Disruption in Bipolar Disorder
Open accessAbstract
Purpose of review Disruptions in circadian rhythms are believed to underlie the illness course of bipolar disorder (BD). This review evaluates recent studies on the treatment of circadian dysfunction in BD.Recent findings Targeted social rhythm therapy may be useful for bipolar depression though some studies suggest that a non-targeted psychosocial or pharmacological intervention may be just as efficacious. Lithium holds potential for addressing circadian dysfunction in BD. Blue-blocking therapy may be useful for mania and midday bright light therapy may relieve depression.Conclusions Psychosocial, pharmacological, and light-based approaches are promising avenues for treating circadian dysfunction in BD.
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Normalizing and stabilizing circadian rhythms through lithium or other methods has proven an effective therapy for ameliorating episodes of depression and mania, and for preventing relapse into these states.
“The approach of normalizing and stabilizing circadian rhythms, through lithium or other methods, has proven an effective therapy for ameliorating episodes of depression and mania, and for preventing relapse into these states124,125.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [125]
The Psychosocial Interventions section (page unavailable) reports that IPSRT stabilized social rhythms and reduced the likelihood of another mood episode; it also describes improvements in depressive symptoms, with mixed findings for mania. But the Pharmacological Interventions section (page unavailable) says lithium’s circadian benefits are suggested by the evidence and that few studies have tested it specifically for circadian dysfunction. The review therefore does not establish that normalizing rhythms through lithium or other methods is a proven therapy for both acute episodes and relapse prevention. (LLM, conf=0.88)
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References 76 · Cited by 102
Research works printed but not linked: 2
- [14]Lewy AJ. Biochemistry and regulation of mammalian melatonin production: Elsevier biomedical. New York; 1983.
- [75]Keltner NL, Folks DG. Alternatives to lithium in the treatment of bipolar disorder. Perspect Psychiatr Care. 1991; 27(2): 36– 7. 1788043
- Authors
- Gold, A. K., & Kinrys, G.
- Affiliations
- Boston University (US)
- Harvard University (US)
- Corresponding author
- Gold, Alexandra K.
- Venue
- Current Psychiatry Reports
- Published
- 2019-03
- Volume
- 21
- Issue
- 3
- Pages
- 14-14
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- PMC
- PMC6812517
- OpenAlex
- W2920676010
- Cited by
- 102
- References
- 76
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 25 · 2023: 17 · 2022: 14 · 2021: 12 · 2020: 5 · 2019: 2
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Agency for Healthcare Research and Quality (R01HS019371)
- National Institute of Mental Health (F31MH116557)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- bipolar disorder, circadian rhythm disruption, circadian dysfunction, lithium, bright light therapy, bipolar depression, mania, phototherapy, psychosocial interventions
- MeSH terms
- Bipolar Disorder, Circadian Rhythm, Depression, Depressive Disorder, Humans, Phototherapy, Lithium Compounds
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