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Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED

Sebastianelli, A., Spatafora, P., Morselli, S., Vignozzi, L., Serni, S., McVary, K. T., Kaplan, S., Gravas, S., Chapple, C., Gacci, Mauro·2020·Current Urology Reports
DOI 10.1007/s11934-020-01009-7
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Abstract

Purpose of Review: Aim of our systematic review is to evaluate and summarize the efficacy and safety of tadalafil alone or in combination with tamsulosin for the management of lower urinary tract symptoms (LUTS)/benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). Recent Findings: Daily tadalafil, in particular 5 mg, according to retrieved studies, appears to be both safe and effective in treating LUTS/BPH and ED, compared with placebo or tamsulosin. The combination of daily tadalafil 5 mg and tamsulosin 0.4 mg allows a better improvement of LUTS compared with both the monotherapies, even if with an increased, but acceptable and tolerated, adverse events rate. After discontinuation of tamsulosin or tadalafil in patients previously treated with their combination, the improvement of LUTS retains significance compared with baseline. Summary: Tadalafil 5 mg should be considered a primary treatment option for patients with LUTS/BPH and ED. Evidence highlight an excellent tolerability, safety, and effectiveness profile, both alone or in combination with tamsulosin 0.4 mg. A better efficacy on LUTS relief has been observed for combination therapy, preserving also sexual function. The further switch to monotherapy allows to preserve LUTS relief, but tadalafil only is able to retain ED improvement. Our results support the evidence for a more and more tailored and modular LUTS treatment.

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Cited by

Metadata

Authors
Sebastianelli, A., Spatafora, P., Morselli, S., Vignozzi, L., Serni, S., McVary, K. T., Kaplan, S., Gravas, S., Chapple, C., & Gacci, M.
Venue
Current Urology Reports
Publisher
Springer Science and Business Media LLC
Published
2020-10-27
Volume
21
Issue
12
ISSN
  • 1527-2737
  • 1534-6285
DOI
10.1007/s11934-020-01009-7
Cited by
37
References
0
Language
en
Licence
Funders
Università degli Studi di Firenze

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