Cited by 119Inflammatory Bowel DiseaseGut microbiota and healthProbiotics and Fermented Foods

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

The gut microbiome as a target for IBD treatment: are we there yet

Knox, Natalie C., Forbes, Jessica D., Van Domselaar, Gary, Bernstein, Charles N.·2019·Current Treatment Options in Gastroenterology

DOI 10.1007/s11938-019-00221-w

Open this paper in CoChat — free account

Abstract

Purpose of review This review aims to highlight recent research on the gut microbiome in IBD and the application of microbiome-modulating therapies for the treatment of IBD including the use of the microbiome as an indicator for disease severity and treatment response. Recent findings Despite the high number of gut microbiome studies and emerging evidence supporting the gut microbiome's involvement in disease pathogenesis, no single microorganism has been identified as a pathogenic agent in IBD. Retrospective studies and meta-analyses on antibiotic use in ulcerative colitis and Crohn's disease and long-term outcomes are conflicting. Similarly, the use of probiotics for the treatment of IBD remains inconclusive; however, some encouraging results are emerging as microbial concoctions are optimized to include beneficial bacterial strains. Fecal microbial transplantation (FMT) is currently emerging as one of the more promising microbiome-modulating IBD therapies. FMT studies in ulcerative colitis have shown improved remission rates compared to placebo; however, relatively small study sample sizes and varied treatment methods, limit definitive conclusions. With clear evidence of an IBD gut dysbiosis, novel therapies to treat and prevent disease relapse will undoubtedly require a microbiome-modulating approach. The complexity and variability of IBD disease pathogenesis (disease phenotype, gut microbiome, host genetic susceptibility, and environmental factors) will likely require a personalized and multidimensional treatment approach where microbiome-modulating therapy is coupled with other therapies to target other IBD disease components.

Integrity signals

Registry

Crossref · 10.1007/s11938-019-00221-w

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
Ng, S. C., Shi, H. Y., Hamidi, N., Underwood, F. E., Tang, W., Benchimol, E. I., Panaccione, R., Ghosh, S., Wu, J. C. Y., Chan, F. K. L., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32448-0 · Cited by 6,087
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Gevers, D., Kugathasan, S., Denson, L. A., Vázquez-Baeza, Y., Van Treuren, W., Ren, B., Schwager, E., Knights, D., Song, S. J., Yassour, M., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.005 · Cited by 3,220
Environment dominates over host genetics in shaping human gut microbiota
Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859
Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation
Dethlefsen, L., & Relman, D. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000087107 · Cited by 2,421
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Immunopathogenesis of IBD: current state of the art
de Souza, H. S. P., & Fiocchi, C. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.186 · Cited by 1,551
Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial
Moayyedi, P., Surette, M. G., Kim, P. T., Libertucci, J., Wolfe, M., Onischi, C., Armstrong, D., Marshall, J. K., Kassam, Z., Reinisch, W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.001 · Cited by 1,499
Fungal microbiota dysbiosis in IBD
Sokol, H., Leducq, V., Aschard, H., Pham, H., Jégou, S., Landman, C., Cohen, D., Liguori, G., Bourrier, A., Nion–Larmurier, I., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-310746 · Cited by 1,382
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease
Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.002 · Cited by 1,285
Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial
Paramsothy, S., Kamm, M. A., Kaakoush, N. O., Walsh, A. J., van den Bogaerde, J., Samuel, D., Leong, R. W. L., Connor, S., Ng, W., Paramsothy, R., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30182-4 · Cited by 1,276

Show all 54 references

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Fucoidan Ameliorated Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating Gut Microbiota and Bile Acid Metabolism
Liu, X., Zhang, Y., Li, W., Zhang, B., Yin, J., Liuqi, S., Wang, J., Peng, B., & Wang, S. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06417 · Cited by 289
Leveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211
Involvement of Probiotics and Postbiotics in the Immune System Modulation
Yeşilyurt, N., Yılmaz, B., Ağagündüz, D., & Capasso, R. (2021) · Biologics · doi:10.3390/biologics1020006 · Cited by 222
A 12‐month pilot study outcomes of vagus nerve stimulation in Crohn's disease
Sinniger, V., Sonia Pellissier, A., Fauvelle, F., Trocmé, C., Hoffmann, D., Vercueil, L., Cracowski, J., Olivier David, A., & Bonaz, B. L. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13911 · Cited by 187
Stress triggers flare of inflammatory bowel disease in children and adults
Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171
L-arginine metabolism as pivotal interface of mutual host–microbe interactions in the gut
Nüse, B., Holland, T., Rauh, M., Gerlach, R. G., & Mattner, J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2222961 · Cited by 135
Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation
Yao, M., Lu, Y., Zhang, T., Xie, J., Han, S., Zhang, S., Fei, Y., Ling, Z., Wu, J., Hu, Y., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00228-1 · Cited by 120
Metabolic modelling reveals broad changes in gut microbial metabolism in inflammatory bowel disease patients with dysbiosis
Heinken, A., Hertel, J., & Thiele, I. (2021) · npj Systems Biology and Applications · doi:10.1038/s41540-021-00178-6 · Cited by 93
Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis
Ke, H., Li, F., Deng, W., Li, Z., Wang, S., Lv, P., & Chen, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.726707 · Cited by 95
Manipulating resident microbiota to enhance regulatory immune function to treat inflammatory bowel diseases
Mishima, Y., & Sartor, R. B. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01618-1 · Cited by 91
Arginase impedes the resolution of colitis by altering the microbiome and metabolome
Baier, J., Gänsbauer, M., Gießler, C., Arnold, H., Muske, M., Schleicher, U., Lukassen, S., Ekici, A. B., Rauh, M., Daniel, C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci126923 · Cited by 87
The Gut Microbiome in Inflammatory Bowel Disease: Lessons Learned From Other Immune-Mediated Inflammatory Diseases
Knox, N., Forbes, J. D., Peterson, C.-L., Domselaar, G. V., & Bernstein, C. N. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000305 · Cited by 87
Self-citation
Fungal microbiome in inflammatory bowel disease: a critical assessment
Underhill, D. M., & Braun, J. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155786 · Cited by 88
Diarrhea Induced by Small Molecule Tyrosine Kinase Inhibitors Compared With Chemotherapy: Potential Role of the Microbiome
Secombe, K. R., Sebille, Y. Z. A. V., Mayo, B. J., Coller, J. K., Gibson, R. J., & Bowen, J. M. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420928493 · Cited by 77
Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches
Alshehri, D., Saadah, O. I., Mosli, M. H., Edris, S., Al-Hindi, R. R., & Bahieldin, A. (2020) · Biomolecules and Biomedicine · doi:10.17305/bjbms.2020.5016 · Cited by 82
Targeting Carbohydrates and Polyphenols for a Healthy Microbiome and Healthy Weight
Hul, M. V., & Cani, P. D. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-00281-5 · Cited by 80
Role of Carbon Monoxide in Host–Gut Microbiome Communication
Hopper, C., Cruz, L. K. D. L., Lyles, K. V. M., Wareham, L. K., Gilbert, J. A., Eichenbaum, Z., Magierowski, M., Poole, R. K., Wollborn, J., & Wang, B. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00586 · Cited by 73
Bacterial and Fungal Profiles as Markers of Infliximab Drug Response in Inflammatory Bowel Disease
Ventin-Holmberg, R., Eberl, A., Saqib, S., Korpela, K., Virtanen, S., Sipponen, T. M., Salonen, A., Saavalainen, P., & Nissilä, E. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa252 · Cited by 72
Drug delivery to the inflamed intestinal mucosa – targeting technologies and human cell culture models for better therapies of IBD
Hartwig, O., Boushehri, M. A. S., Shalaby, K. S., Loretz, B., Lamprecht, A., & Lehr, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113828 · Cited by 72
The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease
Xu, X., Ocansey, D. K. W., Hang, S., Wang, B., Amoah, S., Yi, C., Zhang, X., Liu, L., & Mao, F. (2022) · Gut Pathogens · doi:10.1186/s13099-022-00499-9 · Cited by 73
Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits
Hanscom, M., Loane, D. J., Aubretch, T., Leser, J. M., Molesworth, K., Hedgekar, N., Ritzel, R. M., Abulwerdi, G. A., Shea‐Donohue, T., & Faden, A. I. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02067-x · Cited by 61
Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis
Wipperman, M. F., Bhattarai, S. K., Vorkas, C. K., Maringanti, V. S., Taur, Y., Mathurin, L. D., McAulay, K., Vilbrun, S. C., Francois, D., Bean, J. M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21475-y · Cited by 63
Homeostasis and Dysbiosis of the Intestinal Microbiota: Comparing Hallmarks of a Healthy State with Changes in Inflammatory Bowel Disease
Talapko, J., Včev, A., Meštrović, T., Pustijanac, E., Jukić, M., & Škrlec, I. (2022) · Microorganisms · doi:10.3390/microorganisms10122405 · Cited by 63
Fucose Ameliorate Intestinal Inflammation Through Modulating the Crosstalk Between Bile Acids and Gut Microbiota in a Chronic Colitis Murine Model
Ke, J., Li, Y., Han, C., He, R., Lin, R., Qian, W., & Hou, X. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa007 · Cited by 58
Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis
Abdel-Rahman, L. I. H., & Morgan, X. C. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac194 · Cited by 56
Novel Gut Microbiota Patterns Involved in the Attenuation of Dextran Sodium Sulfate-Induced Mouse Colitis Mediated by Glycerol Monolaurate via Inducing Anti-inflammatory Responses
Mo, Q., Liu, T., Fu, A., Ruan, S., Zhong, H., Tang, J., Zhao, M., Li, Y., Zhu, S., Cai, H., et al. (2021) · mBio · doi:10.1128/mbio.02148-21 · Cited by 50
Comparative of the Effectiveness and Safety of Biological Agents, Tofacitinib, and Fecal Microbiota Transplantation in Ulcerative Colitis: Systematic Review and Network Meta-Analysis
Zhou, H., Guo, B., Lufumpa, E., Li, X., Chen, L., Meng, X. L., & Li, B. (2020) · Immunological Investigations · doi:10.1080/08820139.2020.1714650 · Cited by 45
The effectiveness of multi-session FMT treatment in active ulcerative colitis patients: A pilot study
Mańkowska-Wierzbicka, D., Stelmach-Mardas, M., Gabryel, M., Tomczak, H., Skrzypczak-Zielińska, M., Zakerska-Banaszak, O., Sowińska, A., Mahadea, D., Baturo, A., Wolko, Ł., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8080268 · Cited by 39
Management of Clostridioides difficile infection in patients with inflammatory bowel disease
Khanna, S. (2020) · Intestinal Research · doi:10.5217/ir.2020.00045 · Cited by 41
m6A modification in inflammatory bowel disease provides new insights into clinical applications
Zhang, J., Song, B., Zeng, Y., Xu, C., Gao, L., Guo, Y., & Liu, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114298 · Cited by 34
Diosmin alleviates ulcerative colitis in mice by increasing Akkermansia muciniphila abundance, improving intestinal barrier function, and modulating the NF-κB and Nrf2 pathways
Salem, M. B., El-Lakkany, N. M., el-Din, S. H. S., Hammam, O. A., & Samir, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27527 · Cited by 33
Complex Responses to Hydrogen Peroxide and Hypochlorous Acid by the Probiotic Bacterium Lactobacillus reuteri
Thakur, P. B., Long, A. R., Nelson, B. J., Kumar, R., Rosenberg, A. F., & Gray, M. J. (2019) · mSystems · doi:10.1128/msystems.00453-19 · Cited by 33
Microbiota-targeted therapies in inflammation resolution
Strati, F., Lattanzi, G., Amoroso, C., & Facciotti, F. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101599 · Cited by 31
Microbes with higher metabolic independence are enriched in human gut microbiomes under stressPreprint
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2023) · eLife · doi:10.7554/elife.89862 · Cited by 33
Bacterial cross talk with gut microbiome and its implications: a short review
Shastry, R. P., & Rekha, P. D. (2020) · Folia Microbiologica · doi:10.1007/s12223-020-00821-5 · Cited by 29
Changes in the Intestinal Microbiota Are Seen Following Treatment with Infliximab in Children with Crohn’s Disease
Kowalska‐Duplaga, K., Kapusta, P., Gosiewski, T., Sroka-Oleksiak, A., Ludwig‐Słomczyńska, A. H., Wołkow, P. P., & Fyderek, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030687 · Cited by 28
Changes in the Intestinal Microbiota of Patients with Inflammatory Bowel Disease with Clinical Remission during an 8-Week Infliximab Infusion Cycle
Seong, G., Kim, N., Joung, J., Kim, E. R., Chang, D. K., Chun, J., Hong, S. N., & Kim, Y. (2020) · Microorganisms · doi:10.3390/microorganisms8060874 · Cited by 27
Lactobacillus rhamnosus 1.0320 Postbiotics Ameliorate Dextran Sodium Sulfate-Induced Colonic Inflammation and Oxidative Stress by Regulating the Intestinal Barrier and Gut Microbiota
Zhang, J., Duan, X., Chen, X., Qian, S., Ma, J., Jiang, Z., & Hou, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06303 · Cited by 26
Gastrointestinal microbiota-directed nutritional and therapeutic interventions for inflammatory bowel disease: opportunities and challenges
Paudel, D., Nair, D. V. T., Joseph, G., Castro, R., Tiwari, A. K., & Singh, V. (2023) · Gastroenterology report · doi:10.1093/gastro/goae033 · Cited by 26
Diversion Colitis and Probiotic Stimulation: Effects of Bowel Stimulation Prior to Ileostomy Closure
Rodríguez-Padilla, Á., Morales-Martín, G., Quintero, R. P., Rada, R., Gómez-Salgado, J. C., & Ruíz-Frutos, C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.654573 · Cited by 23
Microbes with higher metabolic independence are enriched in human gut microbiomes under stress
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2025) · eLife · doi:10.1101/2023.05.10.540289 · Cited by 29
Methodology for biomarker discovery with reproducibility in microbiome data using machine learning
Rojas-Velázquez, D., Kidwai, S., Kraneveld, A. D., Tonda, A. P., Oberski, D. L., Garssen, J., & Lopez‐Rincon, A. (2024) · BMC Bioinformatics · doi:10.1186/s12859-024-05639-3 · Cited by 26
Microbiome-Mediated Immune Signaling in Inflammatory Bowel Disease and Colorectal Cancer: Support From Meta-omics Data
Pratt, M., Forbes, J. D., Knox, N., Bernstein, C. N., & Domselaar, G. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716604 · Cited by 23
Self-citation
Enteral Nutrition Supplemented with Transforming Growth Factor-β, Colostrum, Probiotics, and Other Nutritional Compounds in the Treatment of Patients with Inflammatory Bowel Disease
Triantafillidis, J. K., Tzouvala, M., & Triantafyllidi, E. (2020) · Nutrients · doi:10.3390/nu12041048 · Cited by 23
Specific Bacterial Cell Wall Components Influence the Stability of Coxsackievirus B3
Dhalech, A. H., Fuller, T. D., & Robinson, C. M. (2021) · Journal of Virology · doi:10.1128/jvi.01424-21 · Cited by 20
Emerging Insights on the Interaction Between Anticancer and Immunosuppressant Drugs and Intestinal Microbiota in Pediatric Patients
Lucafò, M., Franzin, M., Lagatolla, C., Franca, R., Bramuzzo, M., Stocco, G., & Decorti, G. (2019) · Clinical and Translational Science · doi:10.1111/cts.12722 · Cited by 20
Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease
Adamkova, P., Hradická, P., Skalníková, H. K., Cizkova, V., Vodička, P., Iannaccone, S. F., Kassayová, M., Gancarčíková, S., & Demečková, V. (2022) · Veterinary Sciences · doi:10.3390/vetsci9050238 · Cited by 19
Tetragenococcus halophilus Alleviates Intestinal Inflammation in Mice by Altering Gut Microbiota and Regulating Dendritic Cell Activation via CD83
Islam, S. M. S., Ryu, H.-M., & Sohn, S. (2022) · Cells · doi:10.3390/cells11121903 · Cited by 19
Tieguanyin extracts ameliorated DSS-induced mouse colitis by suppressing inflammation and regulating intestinal microbiota
Zhang, Y., Feng, X., Lin, H., Chen, X., He, P., Wang, Y., & Chu, Q. (2022) · Food & Function · doi:10.1039/d2fo02781j · Cited by 17
Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-κB/MAPK pathway
Qin, X., Liu, Z., Nong, K., Fang, X., Chen, W., Zhang, B., Wu, Y., Wang, Z., Shi, H., Wang, X., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111385 · Cited by 19
Emerging concepts and shifting paradigms for understanding the microbial basis of inflammatory bowel diseases
Kennedy, M. S., & Chang, E. B. (2025) · Journal of Clinical Investigation · doi:10.1172/jci193969 · Cited by 17
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion
Wang, W., Zhai, D., Bai, Y., Xue, K., Deng, L., Ma, L., Du, T., Ye, Z., Qu, D., An, X., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00444-w · Cited by 16
Determine independent gut microbiota-diseases association by eliminating the effects of human lifestyle factors
Zhu, C., Wang, X., Li, J., Jiang, R., Chen, H., Chen, T., & Yang, Y. (2022) · BMC Microbiology · doi:10.1186/s12866-021-02414-9 · Cited by 17
A Review of Hyperbaric Oxygen Therapy for Inflammatory Bowel Disease
Alenazi, N., Alsaeed, H., Alsulami, A., & Alanzi, T. M. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s336678 · Cited by 15
Diversion Colitis: Macro and Microscopic Findings after Probiotics Stimulation
Rodríguez-Padilla, Á., Morales-Martín, G., Quintero, R. P., Gómez-Salgado, J. C., Rada, R., & Ruíz-Frutos, C. (2021) · Biology · doi:10.3390/biology10040303 · Cited by 15
Downregulation of METTL3 enhances TRADD-mediated apoptosis in inflammatory bowel disease
Gong, T., Zeng, Z., Huang, Z., Luo, Y., Cao, X., Li, Z., Zhao, Y., Han, D., Li, D., & Zhong, M. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2799-6 · Cited by 13
Microbial Modulation in Inflammatory Bowel Diseases
Yu, J., & Cheon, J. H. (2022) · Immune Network · doi:10.4110/in.2022.22.e44 · Cited by 13
Candida gut commensalism and inflammatory disease
Gu, Z.-Q., Tseng, K.-Y., & Tsai, Y.-H. (2020) · Medicine in Microecology · doi:10.1016/j.medmic.2020.100008 · Cited by 14
Incorporating plasmid biology and metagenomics into a holistic model of the human gut microbiome
Stockdale, S. R., & Hill, C. (2023) · Current Opinion in Microbiology · doi:10.1016/j.mib.2023.102307 · Cited by 12
Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy
Forte, A., Balistreri, C. R., FEO, M. D., Corte, A. D., Hellstrand, P., Persson, L., & Nilsson, B. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.02.014 · Cited by 13
Unmet needs of drugs for irritable bowel syndrome and inflammatory bowel diseases: interest of vagus nerve stimulation and hypnosis
Bonaz, B. L. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01446-7 · Cited by 13
Nanoparticles as Budding Trends in Colon Drug Delivery for the Management of Ulcerative Colitis
Singh, A., Kaur, K., Mandal, U. K., & Narang, R. K. (2020) · Current Nanomedicine · doi:10.2174/2468187310999200621200615 · Cited by 12
H89 Treatment Reduces Intestinal Inflammation and Candida albicans Overgrowth in Mice
Dumortier, C., Charlet, R., Bettaı̈eb, A., & Jawhara, S. (2020) · Microorganisms · doi:10.3390/microorganisms8122039 · Cited by 13
Intestinal retentive systems – recent advances and emerging approaches
Naik, D. A., Matonis, S., Balakrishnan, G., & Bettinger, C. J. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01842c · Cited by 11
Payload‐free protein nanoparticles target inflamed colons to restore intestinal barrier integrity for effectively treating inflammatory bowel diseases
Yang, M., Shen, H., Zhong, S., Xu, Z., Liu, X., Wu, W., Mao, C., & Yang, M. (2024) · Aggregate · doi:10.1002/agt2.515 · Cited by 11
Beneficial Effect of Faecal Microbiota Transplantation on Mild, Moderate and Severe Dextran Sodium Sulphate-Induced Ulcerative Colitis in a Pseudo Germ-Free Animal Model
Lauko, S., Gancarčíková, S., Hrčková, G., Hajdučková, V., Andrejčáková, Z., Fecskeová, L. K., Bertková, I., Hijová, E., Kamlárová, A., Janíčko, M., et al. (2023) · Biomedicines · doi:10.3390/biomedicines12010043 · Cited by 10
Integrated microbiomic and metabolomics insight into the ameliorating mechanisms of dietary Polygonatum cyrtonema saponin on ulcerative colitis
Xiao, J., Xie, L., Zheng, B., Chen, Y., Xie, J., Huang, H., Hu, X., & Yu, Q. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103871 · Cited by 10
Alternative Therapy in the Prevention of Experimental and Clinical Inflammatory Bowel Disease. Impact of Regular Physical Activity, Intestinal Alkaline Phosphatase and Herbal Products
Bilski, J., Wójcik-Grzybek, D., Danielak, A., Mazur-Biały, A. I., Magierowski, M., Tønnesen, K., Brzozowski, B., Surmiak, M., Magierowska, K., Pajdo, R., et al. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200427090127 · Cited by 10
Microbes with higher metabolic independence are enriched in human gut microbiomes under stressPreprint
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2023) · eLife · doi:10.7554/elife.89862.1 · Cited by 10
Intestinal protozoa and helminths in ulcerative colitis and the influence of anti-parasitic therapy on the course of the disease
Toychiev, A., Navruzov, B., Пазылова, Д. У., Davis, N., Badalova, N., & Осипова, С. О. (2020) · Acta Tropica · doi:10.1016/j.actatropica.2020.105755 · Cited by 11
Single Donor FMT Reverses Microbial/Immune Dysbiosis and Induces Clinical Remission in a Rat Model of Acute Colitis
Adámková, P., Hradicka, P., Gancarčíková, S., Kassayová, M., Ambro, Ľ., Bertková, I., Marônek, M., Iannaccone, S. F., & Demeckova, V. (2021) · Pathogens · doi:10.3390/pathogens10020152 · Cited by 9
IMOVNN: incomplete multi-omics data integration variational neural networks for gut microbiome disease prediction and biomarker identification
Hu, M. Y., Zhu, J., Peng, G., Lu, W., Wang, H., & Xie, Z. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad394 · Cited by 10
Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices
Naik, D. A., Balakrishnan, G., Rajagopalan, M., Huang, X., Trivedi, N., Bhat, A., & Bettinger, C. J. (2023) · Advanced Science · doi:10.1002/advs.202301084 · Cited by 8
Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect
Jirků, M., Lhotská, Z., Frgelecová, L., Kadlecová, O., Petrželková, K. J., Morien, E., & Jirků‐Pomajbíková, K. (2021) · Microorganisms · doi:10.3390/microorganisms9020226 · Cited by 8
ORAL AND ENTERAL NUTRITION THERAPY IN INFLAMMATORY BOWEL DISEASES AMONG THE PEDIATRIC POPULATION: A LITERATURE REVIEW
Souza, G. N., Draghi, P. F., & Yonamine, G. H. (2020) · Revista Paulista de Pediatria · doi:10.1590/1984-0462/2020/38/2019032 · Cited by 8
Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment
Thomas, S., Mercogliano, G., & Prendergast, G. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276910 · Cited by 7
Intestinale Mikrobiota — ein lebenswichtiges „Organ“ mit vielfältigen Funktionen
Konturek, P. C., Konturek, K., Zopf, Y., & Harsch, I. A. (2020) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-020-0228-y · Cited by 7
Small intestinal bacterial overgrowth in inflammatory bowel disease
Shah, A., & Holtmann, G. (2022) · Indian Journal of Gastroenterology · doi:10.1007/s12664-021-01235-y · Cited by 7
Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn’s disease
Budzinski, L., Kang, G.-U., Riedel, R., Sempert, T., Lietz, L., Maier, R., Büttner, J., Bochow, B., Tordai, M. T., Shah, A., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2452250 · Cited by 6
Early fecal microbiome transfer after donor defecation determines response in patients with moderate to severe ulcerative colitis
Singh, A., Mahajan, R., Kahlon, B. K., Dhaliwal, A. S., Midha, V., Mehta, V., Bansal, N., Singh, D., & Sood, A. (2022) · Indian Journal of Gastroenterology · doi:10.1007/s12664-022-01257-0 · Cited by 6
Microbes with higher metabolic independence are enriched in human gut microbiomes under stressPreprint
Veseli, I., Chen, Y. T., Schechter, M. S., Vanni, C., Fogarty, E. C., Watson, A. R., Jabrì, B., Blekhman, R., Willis, A. D., Yu, M., et al. (2024) · eLife · doi:10.7554/elife.89862.2 · Cited by 8
Assessing the Resolution of Methyltransferase-Mediated DNA Optical Mapping
D’Huys, L., Vitale, R., Ruppeka‐Rupeika, E., Goyvaerts, V., Ruckebusch, C., & Hofkens, J. (2021) · ACS Omega · doi:10.1021/acsomega.1c01381 · Cited by 5
Dietary Administration of Black Raspberries and Arsenic Exposure: Changes in the Gut Microbiota and Its Functional Metabolites
Tu, P., Tang, Q., Mo, Z., Niu, H., Hu, Y., Wu, L., Chen, Z., Wang, X., & Gao, B. (2023) · Metabolites · doi:10.3390/metabo13020207 · Cited by 5
Gut Microbes: The Gut Brain Connection
Lynch, C. M. K., O’Riordan, K. J., Clarke, G. A., & Cryan, J. F. (2023) · Springer eBooks · doi:10.1007/978-3-031-46712-7_4 · Cited by 5
Perioperative Considerations for the Surgical Treatment of Crohn’s Disease with Discussion on Surgical Antibiotics Practices and Impact on the Gut Microbiome
Olson, S. L., Welton, L. L., & Jahansouz, C. (2024) · Antibiotics · doi:10.3390/antibiotics13040317 · Cited by 5
Assessing the effects of tofacitinib on the gut microbiome in inflammatory bowel disease
Favaron, A., Sangfuang, N., McCoubrey, L. E., Awad, A., Ghyselinck, J., Marzorati, M., Verstrepen, L., Munck, J. D., Medts, J. D., Basit, A. W., et al. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107365 · Cited by 5
Gut Microbiota-Mediated Immunomodulatory Effects of Lactobacillus rhamnosus HDB1258 Cultured in the Lava Seawater in the Colitis Mouse Model
Kim, K., Song, J., Yang, S.-J., Choi, J.-W., Sohn, J., Han, S., Shin, Y.-J., Lee, D.-Y., Lee, S., & Kim, D. (2021) · Journal of Medicinal Food · doi:10.1089/jmf.2021.k.0103 · Cited by 4
Complementary and Alternative Medicine
Hay, W., Steinke, L., & Foster, L. (2022) · Springer eBooks · doi:10.1007/978-3-030-54441-6_143 · Cited by 4
Are We Ready to Reclassify Crohn’s Disease Using Molecular Classification?
Kamal, S., Parkash, N., Beattie, W., Christensen, B., & Segal, J. P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185786 · Cited by 5
L-arginine as a novel target for clinical intervention in inflammatory bowel disease
Nüse, B., & Mattner, J. (2021) · Exploration of Immunology · doi:10.37349/ei.2021.00008 · Cited by 4
Complex responses to inflammatory oxidants by the probiotic bacterium Lactobacillus reuteriPreprint
Thakur, P. B., Long, A. R., Nelson, B. J., Kumar, R., Rosenberg, A. F., & Gray, M. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/605881 · Cited by 4
Systematic interrogation of the distinct metabolic potential in gut microbiomes of inflammatory bowel disease patients with dysbiosisPreprint
Heinken, A., & Thiele, I. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/640649 · Cited by 5
High-resolution QTL mapping with Diversity Outbred mice identifies genetic variants that impact gut microbiome compositionPreprint
Schlamp, F., Zhang, D. Y., Beltrán, J. F., Cosgrove, E. J., Šimeček, P., Edwards, M. M., Goodrich, J. K., Ley, R. E., Pack, A. I., Churchill, G. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/722744 · Cited by 3
Current insight into enteropathogens in flare-up ulcerative colitis. An observational study
Hassan, E. A., Rehim, A. S. E.-D. A., Ahmed, A. O., Salim, S. M. A. E., Soliman, A. M. A., Rashed, H. G., & El‐Kareem, D. M. A. (2023) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002563 · Cited by 2
The role of the yycF gene in regulating biofilm formation and probiotic properties in Lactobacillus reuteri.
Wang, X., Bai, M., Li, J., Yu, X., Li, P., Ding, X., & Duan, J. (2026) · Food Research International · doi:10.1016/j.foodres.2025.117950 · Cited by 1
Advances in Gut Microbiome and Metabolomics Research in the Comorbidity of Inflammatory Bowel Disease and Depressive Disorder
Zhao, C., Lao, J., Cao, J., Yang, Y., Liu, C., & Tang, F. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.70173 · Cited by 1
Probiotics, Prebiotics, and Synbiotics in Human Health
Wells, O. L., Mishra, S. P., & Yadav, H. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160950-00086 · Cited by 2
Complementary and Alternative Medicine
Hay, W., Steinke, L., & Foster, L. (2020) · Springer eBooks · doi:10.1007/978-1-4939-0779-3_143-1 · Cited by 1
Is the New Approach in Inflammatory Bowel Disease Treat-to-Target?
Vinod Kumar, P. (2021) · Internationale Pharmaceutica Sciencia · doi:10.31531/2231-5896.1000111

Authors: Knox, N. C., Forbes, J. D., Van Domselaar, G., & Bernstein, C. N.
Affiliations: Public Health Agency of Canada (CA)
University of Toronto (CA)
University of Manitoba (CA)
Corresponding author: Bernstein, Charles N.
ORCID: Knox, Natalie C.
Bernstein, Charles N.
Venue: Current Treatment Options in Gastroenterology
Publisher: Springer Science and Business Media LLC
Published: 2019-01-19
Volume: 17
Issue: 1
Pages: 115-126
ISSN: 1092-8472 (ISSN-L)
1534-309X
DOI: 10.1007/s11938-019-00221-w
OpenAlex: W2911082921
Cited by: 117
References: 54
Citations by year: 2026: 1 · 2025: 7 · 2024: 10 · 2023: 19 · 2022: 19 · 2021: 28 · 2020: 22 · 2019: 11
FWCI: 2.65
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Treatment Options in Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, inflammatory bowel disease, fecal microbiota transplantation, probiotics, antibiotic use, ulcerative colitis, Crohn's disease, gut dysbiosis, disease severity markers, treatment response, personalized medicine, relapse prevention

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The gut microbiome as a target for IBD treatment: are we there yet

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Citations

Cites

Cited by

Related

Metadata

Record

About these checks