CoChat
Sign Up
Cited by 41Aluminum toxicity and tolerance in plants and animalsEffects and risks of endocrine disrupting chemicalsHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record.

Effects of Subchronic Aluminum Exposure on the Reproductive Function in Female Rats

Wang, Nan, She, Yue, Zhu, Yanzhu, Zhao, Hansong, Shao, Bing, Sun, Hao, Hu, Chongwei, Li, Yanfei·2012·Biological Trace Element Research
DOI 10.1007/s12011-011-9200-0
Open this paper in CoChat — free account

Abstract

The aim of this study was to investigate the effects of aluminum (Al) exposure on the reproductive function in female rats. Forty female Wistar (5 weeks old) rats, weighing 110-120 g, were divided randomly into four groups. They were orally administrated with 0, 64.18, 128.36, and 256.72 mg aluminum chloride (AlCl(3)) per kilogram body weight in drinking water for 120 days. Levels of Al, estrogen (E(2)), progestogen (P), testosterone (T), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in serum were measured at the end of experiment. The results showed that levels of E(2), P, FSH, and LH were significantly lower and Al concentration was significantly higher in all three Al-treated groups than those in the control group (GC). The level of T was significantly higher in the low- and medium-dose groups (GL and GM) (P < 0.05) but not in high-dose group (GH) compared with GC. The results suggest that the reproductive function of female rats is inhibited under long-term Al exposure in an Al dose-dependent manner.

Overview

Integrity signals

Registry

Crossref · 10.1007/s12011-011-9200-0

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Exposed embryonic chicks and rat fetuses developed congenital myocardial defects.

    “Exposed embryonic chicks and rat fetuses developed congenital myocardial defects (Wang et al., 2012; El Mazoudy and Bekhet, 2016).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Wang et al., 2012

  • There was a significant association between increased maternal hair Al contents and risk of total congenital heart defects in offspring, especially in subtypes such as septal defects, conotruncal defects and right ventricular outflow obstruction in female rats.

    “There was significant association between increased maternal hair Al contents and risk of total congenital heart defects in offspring, especially in subtypes such as septal defects, conotruncal defects and right ventricular outflow obstruction in female rats (Wang et al., 2012).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Wang et al., 2012

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 34

  1. Rengel Z (2004) Aluminium cycling in the soil–plant–animal–human continuum. Biometals 17:669–689 · DOI
  2. Varner JA, Jensen KF, Horvath W, Isaacson RL (1998) Chronic administration of aluminum–fluoride or sodium–fluoride to rats in drinking water: alterations in neuronal and cerebrovascular integrity. Brain Res 784:284–298 · DOI
  3. Murphy EJ, Roberts E, Anderson DK, Horrocks LA (1993) Cytotoxicity of aluminum silicates in primary neuronal cultures. Neuroscience 57:483–490 · DOI
  4. Alexandra T, Eugenia D, Diana B, Snejana P (2010) The consequences of aluminium sulphate intake on exposure and integrity biomarkers in female rats at sexual maturity (two generation study). HVM Bioflux 2:11–18
  5. Colomina MT, Roig JL, Torrente M, Vicens P, Domingo JL (2005) Concurrent exposure to aluminum and stress during pregnancy in rats: Effects on postnatal development and behavior of the offspring. Neurotoxicol Teratol 27:565–574 · DOI
  6. Zhang LC, Li XW, Gu QY, Zhu YZ, Zhao HS, Li YF, Zhang ZG (2010) Effects of subchronic aluminum exposure on serum concentrations of iron and iron-associated proteins in rats. Biol Trace Elem Res. doi: 10.1007/s12011-010-8725-y · DOI · Paper page
  7. He QF, Li YJ, You LL, Zhang WC (2009) Study on productive endocrine system toxicity of subchronic cadmium exposure in female rats. Journal of Tianjin Agricultural University 16:11–13
  8. Fan JJ (2008) A rapid graphite furnace atomic absorption spectrometric method for the determination of aluminum and Nie in food. HN Sci 26:35–38
  9. Guo CH, Lu YF, Hsu G-SW (2005) The influence of aluminum exposure on male reproduction and offspring in mice. Environ Toxicol Pharmacol 20:135–141 · DOI · Paper page
  10. Yousef MI, Kamel KI, El-Guendi MI, El-Demerdash FM (2007) An in vitro study on reproductive toxicity of aluminum chloride on rabbit sperm: the protective role of some antioxidants. Toxicology 239:213–223 · DOI · Paper page
  11. Cherroret G, Desor D, Hutin MF, Burnel D, Capolaghi B, Lehr PR (1996) Effects of aluminum chloride on normal and uremic adult male rats. Tissue distribution, brain acetyltransferase activity, and some biological variables. Biol Trace Elem Res 54:43–53 · DOI
  12. Li XW, Hu CW, Zhu YZ, Sun H, Li YF, Zhang ZG (2010) Effects of aluminum exposure on bone mineral, density, mineral, and trace elements in rats. Biol Trace Elem Res. doi: 10.1007/s12011-010-8861-4 · DOI
  13. Correia TG, Narcizo AM, Bianchini A, Moreira RG (2010) Aluminum as an endocrine disruptor in female Nile tilapia (Oreochromis niloticus). Comp Biochem Physiol C Toxicol Pharmacol 151:461–466 · DOI
  14. Da Silva FT, De Bittencourt BF, Sampaio FJ, Da Fonte RC (2010) Effects of maternal undernutrition during lactation on estrogen and androgen receptor expressions in rat ovary at puberty. Nutrition 26:993–999 · DOI
  15. Goldenberg RL, Vaitukaitis JL, Ross GT (1972) Estrogen and follicle stimulation hormone interactions on follicle growth in rats. Endocrinology 90:1492–1498 · DOI
  16. Welsh TH Jr, Zhuang LZ, Hsueh AJ (1983) Estrogen augmentation of gonadotropin-stimulated progestin biosynthesis in cultured rat granulosa cells. Endocrinology 112:1916–1924 · DOI
  17. Roberts AJ, Skinner MK (1990) Estrogen regulation of thecal cell steroidogenesis and differentiation: thecal cell-granulosa cell interactions. Mol Endocrinol 127:2918–2929 · DOI
  18. Robker RL, Richards JS (1998) Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1. Mol Endocrinol 12:924–940 · DOI
  19. Robker RL, Richards JS (1998) Hormonal control of the cell cycle in ovarian cells: proliferation versus differentiation. Biol Reprod 59:476–482 · DOI
  20. Drummond AE, Findlay JK (1999) The role of estrogen in folliculogenesis. Mol Cell Endocrinol 151:57–64 · DOI
  21. Kumar TR, Wang Y, Lu N, Matzuk MM (1997) Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet 15:201–204 · DOI
  22. Abel MH, Wootton AN, Wilkins V, Huhtaniemi I, Knight PG, Charlton HM (2000) The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction. Endocrinology 141:1795–1803 · DOI
  23. Rao CV (2001) Multiple novel roles of luteinizing hormone. Fertil Steril 76:1097–1100 · DOI
  24. Campbell BK, Scaramuzzi RJ, Webb R (1995) Control of antral follicle development and selection in sheep and cattle. J Reprod Fertil Suppl 49:335–350
  25. Hunter MG, Robinson RS, Mann GE, Webb R (2004) Endocrine and paracrine control of follicular development and ovulation rate in farm species. Anim Reprod Sci 82–83:461–477 · DOI
  26. Niswender GD, Juengel JL, Silva PJ, Rollyson MK, McIntush EW (2000) Mechanisms controlling the function and life span of the corpus luteum. Physiol Rev 80:1–29 · DOI
  27. Liu YX, Hsueh AJ (1986) Synergism between granulose and theca interstitial cells in estrogen biosynthesis by gonadotropin-treated rat ovaries: studies on the two-cell, two-gonadotropin hypothesis using steroid antisera. Biol Reprod 35:27–36 · DOI
  28. Sterneck E, Tessarollo L, Johnson PF (1997) An essential role for C/EBP beta in female reproduction. Genes Dev 11:2153–2162 · DOI
  29. Alexandra T, Eugenia D, Muselin F (2008) The consequences of chronic aluminum sulphate intake on exposure and morphological integrity biomarkers (aluminum level and weight of sexual organs) in female rats. Lucrări Ştiintifice Medicină Veterinară 41:981–985
  30. Chinoy NJ, Patel NT (2001) Effects of sodium fluoride and aluminum chloride on ovary and uterus of mice and their reversal by some antidotes. Fluoride 34:9–20
  31. Zhang W, Pang F, Huang Y, Yan P, Lin W (2008) Cadmium exerts toxic effects on ovarian steroid hormone release in rats. Toxicol Lett 182:18–23 · DOI
  32. Richards JS, Ireland JJ, Rao MC, Bernath GA, Midgley AR Jr, Reichert LE Jr (1976) Ovarian follicular development in the rat: hormone receptor regulation by estradiol, follicle stimulating hormone and luteinizing hormone. Endocrinology 99:1562–1570 · DOI
  33. Wang C, Hsueh AJ, Erickson GF (1981) LH stimulation of estrogen secretion by cultured rat granulosa cells. Mol Cell Endocrinol 24:17–28 · DOI
  34. Wang C, Hsueh AJ, Erickson GF (1982) The role of cyclic AMP in the induction of estrogen and progestin synthesis in cultured granulosa cells. Mol Cell Endocrinol 25:73–83 · DOI

Cited by

Sorted by citations

  • Aluminium toxicosis: a review of toxic actions and effects

    Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395

    “There was significant association between increased maternal hair Al contents and risk of total congenital heart defects in offspring, especially in subtypes such as septal defects, conotruncal defects and right ventricular outflow obstruction in female rats (Wang et al., 2012).”
    Background

Metadata

Authors
Wang, N., She, Y., Zhu, Y., Zhao, H., Shao, B., Sun, H., Hu, C., & Li, Y.
Affiliations
Northeast Agricultural University (CN)
Corresponding author
Li, Yanfei
ORCID
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
2011-09-20
Volume
145
Issue
3
Pages
382-387
ISSN
  • 0163-4984 (ISSN-L)
  • 1559-0720
DOI
10.1007/s12011-011-9200-0
OpenAlex
W1974485684
Cited by
41
References
0
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 1 · 2015: 4 · 2014: 4 · 2013: 3
FWCI
3.08
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Biological Trace Element Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
aluminum exposure, subchronic exposure, female reproduction, aluminum chloride, estrogen, progestogens, testosterone, follicle-stimulating hormone, luteinizing hormone, serum hormone levels, dose-dependent toxicity, reproductive toxicity
MeSH terms
Aluminum, Animals, Body Weight, Estradiol, Female, Follicle Stimulating Hormone, Luteinizing Hormone, Organ Size, Ovary, Progesterone, Reproduction, Testosterone, Rats, Wistar, Rats, Toxicity Tests, Subchronic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review