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Cited by 49Aluminum toxicity and tolerance in plants and animalsSperm and Testicular FunctionHeavy Metal Exposure and Toxicity

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How Bad Is Aluminum Exposure to Reproductive Parameters in Rats?

Mouro, Viviane G. S., Menezes, Tatiana P., Lima, Graziela D. A., Domingues, Rafael R., Souza, Ana Cláudia F., Oliveira, Juraci A., Matta, Sérgio L. P., Machado-Neves, Mariana·2018·Biological Trace Element Research
DOI 10.1007/s12011-017-1139-3
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Abstract

Aluminum (Al) is the most widely distributed metal in the environment and is extensively used in human daily life without any known biological function. It is known that exposure to high concentrations of Al impacts negatively on serum testosterone levels, testicular histomorphometry, and sperm parameters; however, no information is available about the effects of low exposure levels on reproduction. International organizations have established the Al concentration tolerated in drinking water as 3.35 × 10 -4 mg/kg. Therefore, we aimed to compare the effects of long-term exposure to low and high concentrations of Al on male reproductive functions, focusing on testis, epididymis, and sperm parameters. Adult Wistar rats were exposed to aluminum chloride (AlCl 3 ) at 6.7 × 10 -5 , 3.35 × 10 -4 , 10, and 40 mg/kg for 112 days by gavage. Al-exposed animals presented low values of testis and epididymis weight, and serum testosterone levels when compared to controls. The stereology of Leydig cells, epididymis histomorphometry, sperm motility, and structural integrity of sperm membranes changed depending on the Al concentration. In regard to epididymis histomorphometry, the initial segment and caput regions were more affected by Al exposure than distal regions. Otherwise, the histology of testis and epididymis did not alter after the Al exposure, as well as sperm morphology. In summary, we concluded that the consequences of Al exposure at low levels were as negative as high levels on r…

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Metadata

Authors
Mouro, V. G. S., Menezes, T. P., Lima, G. D. A., Domingues, R. R., Souza, A. C. F., Oliveira, J. A., Matta, S. L. P., & Machado-Neves, M.
Affiliations
Universidade Federal de Viçosa (BR)
ORCID
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
2017-09-08
Volume
183
Issue
2
Pages
314-324
ISSN
  • 0163-4984 (ISSN-L)
  • 1559-0720
DOI
10.1007/s12011-017-1139-3
OpenAlex
W2755793181
Cited by
49
References
0
Citations by year
2026: 1 · 2025: 5 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 13 · 2019: 5 · 2018: 1
FWCI
5.11
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biological Trace Element Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
FAPEMIG (APQ-04083-10)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
aluminum exposure, male reproductive toxicity, aluminum chloride, serum testosterone, Leydig cells, sperm motility, sperm membrane integrity, testicular weight, male fertility, rats
MeSH terms
Aluminum, Animals, Body Weight, Epididymis, Male, Organ Size, Reproduction, Sperm Motility, Spermatozoa, Testis, Testosterone, Rats, Wistar, Rats

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