The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profiles in Women with Polycystic Ovary Syndrome: a Randomized Clinical Trial
Abstract
Due to the definitive known effect of magnesium on insulin resistance and the fact that insulin resistance is a main etiology in polycystic ovary syndrome (PCOS), it is assumed the use of magnesium supplements can improve insulin resistance, lipid profiles, and glucose and thus may also play a role in improving the clinical condition of patients with PCOS. We aimed to assess the effects of magnesium supplements on anthropometric, clinical, and metabolic parameters in women suffering from PCOS. This triple-blind randomized clinical trial study was conducted on women aged 15-35 years with PCOS. The patients were randomly assigned to receive a magnesium oxide supplement (250 mg/day for 2 months) or a placebo. The study parameters were evaluated and compared between two groups before as well as 2 months and 5 months after the initial assessment. In total, 40 cases (20 in each group) were recruited in the study. A significant reduction in the serum insulin level (P-value = 0.036) and insulin resistance (p-value = 0.032) was observed in the case group. Prescribing magnesium supplements could also lead to lowering total cholesterol, low-density lipoprotein, and fasting blood sugar along with increasing the level of high-density lipoprotein. We could not find any significant difference in anthropometric parameters as well as the mean systolic and diastolic blood pressures before and after intervention between the two groups. Although the rate of oligomenorrhea significantly decreased in the two study groups, it was no different across the two groups before and also after the intervention. The use of magnesium supplements in patients with PCO, regardless of the etiology or progression of the disease, can greatly improve the metabolic status of these patients by improving insulin resistance and modulating the level of lipid profile.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Further research has revealed varying degrees of IR in different tissues of PCOS patients, including adipose tissues, fibroblasts and skeletal muscle cells8,9.”
In the citing paper
“This suggests that, in addition to systemic IR, PCOS may involve localized IR in the ovaries.”
Citations
Cites
Toprak, O., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney and Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,627
Magnesium in Prevention and Therapy
Gröber, U., Schmidt, J., & Kisters, K. (2015) · Nutrients · doi:10.3390/nu7095388 · Cited by 1,061 · cited 1×
“Also, magnesium has a regulatory role in the function of enzymatic activators by stimulating glycolysis as well as oxidative phosphorylation [10].”
Genetic Basis of Polycystic Ovary Syndrome (PCOS): Current Perspectives
Khan, M. J., Ullah, A., & Basit, S. (2019) · The Application of Clinical Genetics · doi:10.2147/tacg.s200341 · Cited by 419
The Importance of Magnesium in Clinical Healthcare
Schwalfenberg, G., & Genuis, S. J. (2017) · Scientifica · doi:10.1155/2017/4179326 · Cited by 304
DiNicolantonio, J. J., O’Keefe, J. H., & Wilson, W. (2018) · Open Heart · doi:10.1136/openhrt-2017-000668 · Cited by 304
Barbagallo, M. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i10.1152 · Cited by 290
Insulin and the polycystic ovary syndrome
Μacut, D., Bjekić-Macut, J., Rahelić, D., & Doknić, M. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.06.011 · Cited by 277
Smet, M.-E., & McLennan, A. (2018) · Australasian Journal of Ultrasound in Medicine · doi:10.1002/ajum.12096 · Cited by 99
Huang, J., Lu, Y., Cheng, F., Lee, J. N.-Y., & Tsai, L. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-41 · Cited by 84
Factors influencing magnesium consumption among adults in the United States
Tarleton, E. K. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy002 · Cited by 63
Research works printed but not linked: 1
- Mohammad Alizadeh Charandabi S, Mirghafourvand M, Javadzadeh Y, Nezamivand CS (2014) Effect of calcium with and without magnesium on amount and duration of menstrual bleeding in students with primary dysmenorrhea. Iran J Obstet Gynecol Infertil 16(83):1–8
Cited by
Lin, S., Deng, Y., Huang, J., Li, M., Sooranna, S. R., Qin, M., & Tan, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-99622-4 · Cited by 35
Metadata
- Authors
- Shahmoradi, S., Chiti, H., Tavakolizadeh, M., Hatami, R., Motamed, N., & Ghaemi, M.
- Affiliations
- Zanjan University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Hatami, Robabeh
- Venue
- Biological Trace Element Research
- Published
- 2023-07-02
- Volume
- 202
- Issue
- 3
- Pages
- 941-946
- ISSN
- 0163-4984 (ISSN-L)
- 1559-0720
- OpenAlex
- W4382793506
- Cited by
- 25
- References
- 21
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 6
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Update notices
- correction (2023-08-01)
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
- Locations
- Biological Trace Element Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- magnesium supplementation, magnesium oxide, polycystic ovary syndrome, insulin resistance, lipid profile, serum insulin, fasting blood glucose, HDL cholesterol, LDL cholesterol, total cholesterol, oligomenorrhea, blood pressure, anthropometric parameters, women
- MeSH terms
- Adolescent, Adult, Blood Glucose, Double-Blind Method, Female, Humans, Insulin, Insulin Resistance, Lipids, Magnesium, Polycystic Ovary Syndrome, Dietary Supplements, Metabolome, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
