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Recent Progress in Mesenchymal Stem Cell-Derived Exosomes for Skin Wound Repair

Xie, Peilin, Xue, Xiaodong, Li, Xiaodong·2024·Cell Biochemistry and Biophysics
DOI 10.1007/s12013-024-01328-3
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Abstract

Background Exosomes are nanometer-sized, lipid bilayer membrane vesicles that are secreted by various cell types. Mesenchymal stem cells (MSCs) have been shown to exert therapeutic effects through the secretion of exosomes via a paracrine pathway. Functions: Recent studies have demonstrated that MSC-derived exosomes (MSC-Exos) can effectively transport various bioactive substances, including proteins, mRNAs, microRNAs, long non-coding RNAs, circular RNAs, and lipids, into target cells. This process regulates multiple aspects during wound repair, such as the inflammatory response, cell proliferation, migration, differentiation, angiogenesis, and matrix remodeling. Potential applications By promoting wound healing and inhibiting scar formation, MSC-Exos have shown great promise for clinical applications in wound repair. This review highlights the recent advances in our understanding of the role and mechanism of MSC-Exos during wound repair, providing insights into their potential use in future therapeutic strategies.

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Metadata

Authors
Xie, P., Xue, X., & Li, X.
Venue
Cell Biochemistry and Biophysics
Publisher
Springer Science and Business Media LLC
Published
2024-05-29
Volume
82
Issue
3
Pages
1651-1663
ISSN
  • 1085-9195
  • 1559-0283
DOI
10.1007/s12013-024-01328-3
Cited by
9
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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