Cited by 328Immunodeficiency and Autoimmune DisordersNeutrophil, Myeloperoxidase and Oxidative MechanismsBlood disorders and treatments

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Chronic Granulomatous Disease

Holland, Steven M.·2010·Clinical Reviews in Allergy & Immunology

DOI 10.1007/s12016-009-8136-z

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Abstract

Chronic granulomatous disease (CGD) was first described in the 1950s and has become a paradigm for genetic neutrophil diseases. It is characterized by recurrent infections with a narrow spectrum of bacteria and fungi as well as a common set of inflammatory complications most notably including inflammatory bowel disease. Over the last half century major advances in management have profoundly altered the major clinical issues and the life expectancy of CGD. With X-linked and autosomal recessive forms, it has been an important disease for the development of bone marrow transplantation and gene therapy. Some of the recent developments in infectious syndromes, inflammatory complications, and curative approaches are discussed in this review.

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Authors: Holland, S. M.
Affiliations: National Institutes of Health (US)
Corresponding author: Holland, Steven M.
ORCID: Holland, Steven M.
Venue: Clinical Reviews in Allergy & Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-06-09
Volume: 38
Issue: 1
Pages: 3-10
ISSN: 1080-0549 (ISSN-L)
1559-0267
DOI: 10.1007/s12016-009-8136-z
OpenAlex: W2052012325
Cited by: 328
References: 65
Citations by year: 2026: 5 · 2025: 10 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 20 · 2020: 12 · 2019: 16 · 2018: 15 · 2017: 19 · 2016: 21 · 2015: 19 · 2014: 29 · 2013: 43 · 2012: 27
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Clinical Reviews in Allergy & Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
NHLBI Division of Intramural Research
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Keywords: chronic granulomatous disease, neutrophil dysfunction, inflammatory bowel disease, X-linked CGD, autosomal recessive CGD, bone marrow transplantation, gene therapy, inflammatory complications, life expectancy
MeSH terms: Animals, Anti-Bacterial Agents, Antifungal Agents, Granulomatous Disease, Chronic, Humans, Interferon-gamma, Genetic Therapy, Bone Marrow Transplantation, NADPH Oxidases, Mice

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