Tablet and oral liquid L-thyroxine formulation in the treatment of naive hypothyroid patients with Helicobacter pylori infection
Abstract
To compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in naïve hypothyroid subjects with Helicobacter pylori infection. Forty-seven adult naïve hypothyroid subjects with dyspeptic symptoms were investigated with upper endoscopy and divided into: 28 patients with Helicobacter pylori infection (Group A); 15 patients without gastric alterations (group B); 4 patients with autoimmune gastritis were excluded from the study. Subjects were randomly treated with a same dose of LT4 tablet (TAB) or oral liquid formulation (SOL), for 9 months on group A and 6 months on group B. Helicobacter pylori infection was eradicated after 3 months of LT4 treatment. On group A, after 3 months (before Helicobacter pylori eradication), subjects treated with SOL showed a greater thyroid-stimulating hormone reduction (ΔTSH 3-0 : TAB = -4.1 ± 4.6 mU/L; SOL = -7.7 ± 2.5 mU/L; p = 0.029) and a greater homogeneity in the thyroid-stimulating hormone values (TSH 3mo : TAB = 5.7 ± 4.9 mU/L; SOL = 4.1 ± 2.0 mU/L; p = 0.025), compared to LT4 tablet. At 9 months (after 6 months of Helicobacter pylori eradication) mean thyroid-stimulating hormone values were lower in subjects treated with LT4 tablet (TSH 9mo : TAB = 1.8 ± 1.2 mU/L; SOL = 3.2 ± 1.7 mU/L; p = 0.006). On group B no difference were observed, at each time point, in the mean thyroid-stimulating hormone values and thyroid-stimulating hormone variations between two LT4 formulations. LT4 liquid formulation may produce a b…
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Patients with impaired stomach acid secretion require higher levothyroxine doses.
“Several studies demonstrate the requirement of higher levothyroxine doses in patients with stomach acid secretion impairment (Centanni et al., 2006; Ribichini et al., 2017).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Ribichini et al., 2017
Helicobacter pylori treatment improves TSH levels and lowers the required dose of levothyroxine.
“In addition, there are studies that show improved levels of TSH upon Helicobacter pylori treatment that lower the required dose of levothyroxine (Centanni et al., 2006; Ribichini et al., 2017).”
From Thyroid disorders and gastrointestinal dysmotility: an old association (2024) · cites this paper as Ribichini et al., 2017
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References 26 · Cited by 35
- Authors
- Ribichini, D., Fiorini, G., Repaci, A., Castelli, V., Gatta, L., Vaira, D., & Pasquali, R.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Ospedale Versilia (IT)
- Corresponding author
- Ribichini, Danilo
- Pasquali, Renato
- Venue
- Endocrine
- Published
- 2016-11-15
- Volume
- 57
- Issue
- 3
- Pages
- 394-401
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2555994508
- Cited by
- 35
- References
- 26
- Citations by year
- 2026: 1 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Keywords
- levothyroxine, oral liquid formulation, tablet formulation, hypothyroidism, Helicobacter pylori infection, thyroid-stimulating hormone, dyspepsia, Helicobacter pylori eradication, drug formulation comparison
- MeSH terms
- Adult, Anti-Ulcer Agents, Anti-Bacterial Agents, Drug Therapy, Combination, Dyspepsia, Female, Gastritis, Humans, Hypothyroidism, Intestinal Absorption, Male, Middle Aged, Pituitary Gland, Anterior, Severity of Illness Index, Tablets, Thyroid Gland, Thyrotropin, Thyroxine, Helicobacter pylori, Helicobacter Infections, Hormone Replacement Therapy, Young Adult
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