Is levothyroxine requirement the same for tablet and soft gel formulations?
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Data from 104 hypothyroid patients showed that TSH was significantly reduced in the capsule group (1.3 ± 0.9 vs 1.8 ± 1.2 mU/L, P = .02).
“Data from 104 hypothyroid patients showed that TSH was significantly reduced in the capsule group (1.3 ± 0.9 vs 1.8 ± 1.2 mU/L, P = .02) (224).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [224]
It can be postulated that soft gel capsules have superior efficacy over tablets.
“In conclusion, it can be postulated that soft gel capsules have superior efficacy over tablets.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [224]
The difference in TSH between capsule and tablet groups may be related to a more favorable pharmacokinetic profile of soft gel capsules in patients.
“This difference may be related to a more favorable pharmacokinetic profile of soft gel capsules in patients.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [224]
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References 18 · Cited by 17
- Authors
- Di Donna, V., Paragliola, R. M., de Waure, C., Papi, G., Pontecorvi, A., & Corsello, S. M.
- Affiliations
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Corsello, Salvatore Maria
- Venue
- Endocrine
- Published
- 2017-05-02
- Volume
- 59
- Issue
- 2
- Pages
- 458-460
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2611945011
- Cited by
- 17
- References
- 18
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 1
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- levothyroxine, tablet formulation, drug formulation comparison, thyroid hormone replacement, bioavailability
- MeSH terms
- Adult, Aged, Capsules, Drug Compounding, Female, Humans, Male, Middle Aged, Tablets, Thyroidectomy, Thyroxine, Treatment Outcome, Cross-Over Studies, Hormone Replacement Therapy
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