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Cited by 62Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsAmyotrophic Lateral Sclerosis Research

Parkinsonism and Frontotemporal Dementia: The Clinical Overlap

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Espay, Alberto J., Litvan, Irene·2011·Journal of Molecular Neuroscience
DOI 10.1007/s12031-011-9632-1PMC PMC3324113
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Abstract

Frontotemporal dementia is commonly associated with parkinsonism in several sporadic (i.e., progressive supranuclear palsy, corticobasal degeneration) and familial neurodegenerative disorders (i.e., frontotemporal dementia associated with parkinsonism and MAPT or progranulin mutations in chromosome 17). The clinical diagnosis of these disorders may be challenging in view of overlapping clinical features, particularly in speech, language, and behavior. The motor and cognitive phenotypes can be viewed within a spectrum of clinical, pathologic, and genetic disorders with no discrete clinicopathologic correlations but rather lying within a dementia-parkinsonism continuum. Neuroimaging and cerebrospinal fluid analysis can be helpful, but the poor specificity of clinical and imaging features has enormously challenged the development of biological markers that could differentiate these disorders premortem. This gap is critical to bridge in order to allow testing of novel biological therapies that may slow the progression of these proteinopathies.

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  • In cases of bvFTD-associated parkinsonism, tau is the most common underlying proteinopathy.

    “In cases of bvFTD-associated parkinsonism, tau is the most common underlying proteinopathy [20].”

    From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [20]

    The Genetic Investigations section states that most cases of FTLD associated with parkinsonism are tauopathies. That supports the general point, but it does not establish that tau is the most common proteinopathy specifically in behavioral-variant FTD (bvFTD) with parkinsonism. (LLM, conf=0.85)

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Research works printed but not linked: 52

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Authors
Espay, A. J., & Litvan, I.
Affiliations
  • University of Cincinnati (US)
  • University of Louisville (US)
Corresponding author
Litvan, Irene
ORCID
Venue
Journal of Molecular Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2011-09-03
Volume
45
Issue
3
Pages
343-349
ISSN
  • 0895-8696 (ISSN-L)
  • 1559-1166
DOI
10.1007/s12031-011-9632-1
PMC
PMC3324113
OpenAlex
W2072609931
Cited by
62
References
2
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 11 · 2013: 5 · 2012: 3
FWCI
4.18
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Molecular Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Public Health Service (R01 PAS-03-092)
  • National Institute of Mental Health (K23MH092735)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
frontotemporal dementia, parkinsonism, progressive supranuclear palsy, corticobasal degeneration, MAPT mutations, progranulin mutations, diagnosis, differential diagnosis, biomarkers, cerebrospinal fluid analysis, neuroimaging, proteinopathies
MeSH terms
Progranulins, Humans, Supranuclear Palsy, Progressive, tau Proteins, Genetic Predisposition to Disease, Parkinsonian Disorders, Intercellular Signaling Peptides and Proteins, Frontotemporal Dementia

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