The role of Notch signaling in adult neurogenesis
Abstract
Neurogenesis occurs throughout adulthood in the mammalian brain. Newly born neurons are incorporated into the functional networks of both the olfactory bulb and the hippocampal dentate gyrus, and there is growing evidence that adult neurogenesis is important for various brain functions. Continuous neurogenesis is achieved by the coordinated proliferation and differentiation of adult neural stem cells. In this review, we discuss the recent findings concerning the roles of Notch signaling in adult neural stem cells.
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Notch signaling inhibits neural stem cell proliferation in zebrafish and mouse brain.
“However, similar to the injured zebrafish retina, Notch signaling inhibits neural stem cell proliferation in the zebrafish and mouse brain (Chapouton et al., 2010; Imayoshi and Kageyama, 2011; Imayoshi et al., 2010).”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Imayoshi and Kageyama, 2011
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References 58 · Cited by 102
- Authors
- Imayoshi, I., & Kageyama, R.
- Affiliations
- Kyoto University (JP)
- Corresponding author
- Imayoshi, Itaru
- Kageyama, Ryoichiro
- Venue
- Molecular Neurobiology
- Published
- 2011-05-04
- Volume
- 44
- Issue
- 1
- Pages
- 7-12
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2008870234
- Cited by
- 102
- References
- 58
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 5 · 2014: 12 · 2013: 10 · 2012: 8
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Precursory Research for Embryonic Science and Technology
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Notch signaling, adult neurogenesis, neural stem cells, olfactory bulb, dentate gyrus, neural stem cell proliferation, neuronal differentiation, adult brain
- MeSH terms
- Animals, Humans, Signal Transduction, Receptors, Notch, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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