The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The Role of SORL1 in Alzheimer’s Disease
Abstract
Genetic variation in SORL1 gene, also known as LR11, has been identified to associate with Alzheimer's disease (AD) through replicated genetic studies. As a type I transmembrane protein, SORL1 is composed of several distinct domains and belongs to both the low-density lipoprotein receptor (LDLR) family and the vacuolar protein sorting 10 (VPS10) domain receptor family. The level of SORL1 was found to be decreased in the AD brain which positively correlated with β-amyloid (Aβ) accumulation. Emerging data suggests that SORL1 contributes to AD through various pathways, including emerging as a central regulator of the trafficking and processing of amyloid precursor protein (APP), involvement in Aβ destruction, and interaction with ApoE and tau protein. Primarily, SORL1 interacts with distinct sets of cytosolic adaptors for anterograde and retrograde movement of APP between the trans-Golgi network (TGN) and early endosomes, thereby restricting the delivery of the precursor to endocytic compartments that favor amyloidogenic breakdown. In this article, we review recent epidemiological and genetical findings of SORL1 that related with AD and speculate the possible roles of SORL1 in the progression of this disease. Finally, given the potential contributions of SORL1 to AD pathogenesis, targeting SORL1 might present novel opportunities for AD therapy.
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In the citing paper
“SORL1 underexpression has also been associated with an increase in Aβ production by blocking the redirection of endocytosed APP to the trans-Golgi network, which reduces APP processing in endosomes [113, 144, 152].”
From The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? (2019) · cites this paper as [152]
In the citing paper
“SORLA is involved in APP processing, Aβ secretion and Aβ turnover [484].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [484]
Citations
Cites
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
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The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene
Marcusson, E. G., Horazdovsky, B. F., Cereghino, J. L., Gharakhanian, E., & Emr, S. D. (1994) · Cell · doi:10.1016/0092-8674(94)90219-4 · Cited by 439
Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity
Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.-H., Zhong, Z., Shen, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.012 · Cited by 337
Loss of apolipoprotein E receptor LR11 in Alzheimer disease
Scherzer, C. R., Offe, K., Gearing, M., Rees, H. D., Fang, G., Heilman, C. J., Schaller, C., Bujo, H., Levey, A. I., & Lah, J. J. (2004) · Archives of Neurology · doi:10.1001/archneur.61.8.1200 · Cited by 316
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Jacobsen, L., Madsen, P., Moestrup, S. K., Lund, A. H., Tommerup, N., Nykjær, A., Sottrup-Jensen, L., Gliemann, J., & Petersen, C. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31379 · Cited by 253
Offe, K., Dodson, S. E., Shoemaker, J. T., Fritz, J. J., Gearing, M., Levey, A. I., & Lah, J. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4946-05.2006 · Cited by 245
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Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Jiang, T., Yu, J., Tian, Y., & Tan, L. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990155 · Cited by 231
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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease
Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994
Alzheimer’s Disease: An Updated Overview of Its Genetics
Andrade-Guerrero, J., Santiago-Balmaseda, A., Jeronimo-Aguilar, P., Vargas-Rodríguez, I., Cadena-Suárez, A. R., Sánchez-Garibay, C., Pozo-Molina, G., Méndez-Catalá, C. F., Cardenas-Aguayo, M.-D.-C., Diaz-Cintra, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043754 · Cited by 336
The biological pathways of Alzheimer disease: a review
Calabrò, M., Rinaldi, C., Santoro, G., & Crisafulli, C. (2020) · AIMS neuroscience · doi:10.3934/neuroscience.2021005 · Cited by 287
Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212
Noncoding RNAs in Alzheimer's disease
Idda, M. L., Munk, R. B., Abdelmohsen, K., & Gorospe, M. (2018) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1463 · Cited by 211
Metadata
- Authors
- Yin, R.-H., Yu, J.-T., & Tan, L.
- Affiliations
- Qingdao University (CN)
- Corresponding author
- Tan, Lan
- ORCID
- Venue
- Molecular Neurobiology
- Published
- 2014-05-16
- Volume
- 51
- Issue
- 3
- Pages
- 909-918
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2064885915
- Cited by
- 126
- References
- 61
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 17 · 2023: 15 · 2022: 8 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 8 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 4
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- SORL1, Alzheimer's disease, genetic association, amyloid precursor protein, amyloid-beta, APP trafficking, apolipoprotein E, tau protein, trans-Golgi network, early endosomes, amyloidogenic processing, disease progression, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Humans, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, LDL-Receptor Related Proteins, Membrane Transport Proteins, Amyloid Precursor Protein Secretases
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