Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?
Open accessAbstract
Oligodendrocytes, the myelinating cells of the central nervous system, mediate rapid action potential conduction and provide trophic support for axonal as well as neuronal maintenance. Their progenitor cell population is widely distributed in the adult brain and represents a permanent cellular reservoir for oligodendrocyte replacement and myelin plasticity. The recognition of oligodendrocytes, their progeny, and myelin as contributing factors for the pathogenesis and the progression of neurodegenerative disease has recently evolved shaping our understanding of these disorders. In the present review, we aim to highlight studies on oligodendrocytes and their progenitors in neurodegenerative diseases. We dissect oligodendroglial biology and illustrate evolutionary aspects in regard to their importance for neuronal functionality and maintenance of neuronal circuitries. After covering recent studies on oligodendroglia in different neurodegenerative diseases mainly in view of their function as myelinating cells, we focus on the alpha-synucleinopathy multiple system atrophy, a prototypical disorder with a well-defined oligodendroglial pathology.
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Drastic demyelination observed in MSA patients is not accompanied by a severe loss of mature oligodendrocytes.
“The drastic demyelination observed in MSA patients is not accompanied by a severe loss of mature oligodendrocytes [49, 14]”
From Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates (2017) · cites this paper as [14]
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References 213 · Cited by 160
- Authors
- Ettle, B., Schlachetzki, J. C. M., & Winkler, J.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Winkler, Jürgen
- Venue
- Molecular Neurobiology
- Published
- 2015-05-13
- Volume
- 53
- Issue
- 5
- Pages
- 3046-3062
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC4902834
- OpenAlex
- W340928335
- Cited by
- 160
- References
- 213
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 18 · 2023: 15 · 2022: 17 · 2021: 25 · 2020: 21 · 2019: 13 · 2018: 11 · 2017: 12 · 2016: 4
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Molecular Neurobiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- oligodendrocytes, oligodendrocyte precursor cells, myelin, neurodegenerative diseases, multiple system atrophy, synucleinopathies, myelination, myelin plasticity
- MeSH terms
- Animals, Biological Evolution, Humans, Myelin Sheath, Oligodendroglia, Neurodegenerative Diseases
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