Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation
Open accessAbstract
Liver transplantation is a highly complex and challenging field of clinical practice. Although it was originally developed in western countries, it has been further advanced in Asian countries through the use of living donor liver transplantation. This method of transplantation is the only available option in many countries in the Asia-Pacific region due to the lack of deceased organ donation. As a result of this clinical situation, there is a growing need for guidelines that are specific to the Asia-Pacific region. These guidelines provide comprehensive recommendations for evidence-based management throughout the entire process of liver transplantation, covering both deceased and living donor liver transplantation. In addition, the development of these guidelines has been a collaborative effort between medical professionals from various countries in the region. This has allowed for the inclusion of diverse perspectives and experiences, leading to a more comprehensive and effective set of guidelines.
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Liver transplantation is limited by global donor shortages, excessive costs, and long-term adverse effects of immunosuppressive drugs.
“Its application is, however, limited by persistent constraints, including global donor shortages leading to waitlist times and death, excessive costs (surgery, long-term immunosuppression, and follow-up), and long-term adverse effects of infections, metabolic complications, and malignancies associated with immunosuppressive drugs [10, 11].”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [10]
Liver transplantation remains the only curative option for end-stage liver disease.
“Liver transplantation remains the only curative option for end-stage liver disease, and refinements in surgical procedures, immunosuppressive therapy, and postoperative management have significantly enhanced patient survival and quality of life.”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [10]
Advanced stages of cirrhosis often require liver transplantation, which is undermined by donor shortage and logistical setbacks.
“Although early interventions can retard or reverse early injury, advanced stages often call for liver transplantation—a therapy undermined by donor shortage and logistical setbacks.”
From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [10]
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References 991 · Cited by 47
- Authors
- Kim, D.-S., Yoon, Y.-I., Kim, B. K., Choudhury, A., Kulkarni, A., Park, J. Y., Kim, J., Sinn, D. H., Joo, D. J., Choi, Y., Lee, J.-H., Choi, H. J., Yoon, K. T., Yim, S. Y., Park, C.-S., Kim, D.-G., Lee, H. W., Choi, W.-M., Chon, Y. E., Kang, W.-H., Rhu, J., Lee, J. G., Cho, Y., Sung, P. S., Lee, H. A., Kim, J. H., Bae, S. H., Yang, J. M., Suh, K.-S., Al Mahtab, M., Tan, S. S., Abbas, Z., Shresta, A., Alam, S., Arora, A., Kumar, A., Rathi, P., Bhavani, R., Panackel, C., Lee, K. C., Li, J., Yu, M.-L., George, J., Tanwandee, T., Hsieh, S.-Y., Yong, C. C., Rela, M., Lin, H. C., Omata, M., Sarin, S. K., & for Asian Pacific Association for Study of Liver (APASL)
- Affiliations
- Yonsei University (KR)
- Asan Medical Center (KR)
- Institute of Liver and Biliary Sciences (IN)
- Asian Institute of Gastroenterology (IN)
- Samsung Medical Center (KR)
- Seoul National University (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Pusan National University (KR)
- Korea University (KR)
- The Catholic University of Korea Eunpyeong St. Mary's Hospital (KR)
- Ewha Womans University (KR)
- CHA University Bundang Medical Center (KR)
- National Cancer Center (KR)
- Catholic University of Korea (KR)
- Hospital Selayang (MY)
- Sindh Institute of Urology and Transplantation (PK)
- Sir Ganga Ram Hospital (IN)
- University Malaya Medical Centre (MY)
- Aster Medcity (IN)
- Taipei Veterans General Hospital (TW)
- Zhejiang University (CN)
- Kaohsiung Medical University (TW)
- The University of Sydney (AU)
- Mahidol University (TH)
- Linkou Chang Gung Memorial Hospital (TW)
- Yamanashi Prefectural Central Hospital (JP)
- Corresponding author
- Yang, Jin Mo
- Suh, Kyung-Suk
- ORCID
- Kim, Dong-Sik
- Yoon, Young-In
- Kim, Beom Kyung
- Choudhury, Ashok
- Kulkarni, Anand
- Park, Jun Yong
- Sinn, Dong Hyun
- Joo, Dong Jin
- Choi, YoungRok
- Lee, Jeong-Hoon
- Choi, Ho Joong
- Yoon, Ki Tae
- Yim, Sun Young
- Park, Cheon-Soo
- Kim, Deok-Gie
- Lee, Hae Won
- Choi, Won-Mook
- Chon, Young Eun
- Kang, Woo-Hyoung
- Rhu, Jinsoo
- Lee, Jae Geun
- Cho, Yuri
- Sung, Pil Soo
- Lee, Han Ah
- Kim, Ji Hoon
- Bae, Si Hyun
- Yang, Jin Mo
- Suh, Kyung-Suk
- Abbas, Zaigham
- Alam, Shahinul
- Arora, Anil
- Kumar, Ashish
- Rathi, Pravin
- Panackel, Charles
- Yu, Ming-Lung
- George, Jacob
- Tanwandee, Tawesak
- Hsieh, Sen-Yung
- Yong, Chee Chien
- Rela, Mohamed
- Omata, Masao
- Sarin, Shiv Kumar
- Venue
- Hepatology International
- Published
- 2024-02-28
- Volume
- 18
- Issue
- 2
- Pages
- 299-383
- ISSN
- 1936-0533 (ISSN-L)
- 1936-0541
- OpenAlex
- W4392239237
- Cited by
- 47
- References
- 991
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 12
- FWCI
- 19.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Hepatology International (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the organizing committee of the 31st Conference of the Asian Pacific Association for the Study of the Liver
- Topics
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- liver transplantation, living donor liver transplantation, deceased donor liver transplantation, Asia-Pacific region, organ shortage, evidence-based management
- MeSH terms
- Asia, Humans, Liver, Tissue and Organ Procurement, Liver Transplantation, Living Donors
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