Posttraumatic Stress Disorder, Cardiovascular, and Metabolic Disease: A Review of the Evidence
Open accessAbstract
BACKGROUND: Posttraumatic stress disorder (PTSD) is a significant risk factor for cardiovascular and metabolic disease. PURPOSE: The purpose of the current review is to evaluate the evidence suggesting that PTSD increases cardiovascular and metabolic risk factors, and to identify possible biomarkers and psychosocial characteristics and behavioral variables that are associated with these outcomes. METHODS: A systematic literature search in the period of 2002-2009 for PTSD, cardiovascular disease, and metabolic disease was conducted. RESULTS: The literature search yielded 78 studies on PTSD and cardiovascular/metabolic disease and biomarkers. CONCLUSIONS: Although the available literature suggests an association of PTSD with cardiovascular disease and biomarkers, further research must consider potential confounds, incorporate longitudinal designs, and conduct careful PTSD assessments in diverse samples to address gaps in the research literature. Research on metabolic disease and biomarkers suggests an association with PTSD, but has not progressed as far as the cardiovascular research.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several studies demonstrated a relationship between inflammation and PTSD.
“With respect to the potential effects of ketorolac, several studies demonstrated a relationship between inflammation and PTSD.24,25”
From Low dose ketamine infusion for comorbid posttraumatic stress disorder and chronic pain: a randomized double-blind clinical trial (2020) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 222 · Cited by 263
- Authors
- Dedert, E. A., Calhoun, P. S., Watkins, L. L., Sherwood, A., & Beckham, J. C.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Corresponding author
- Dedert, Eric A.
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02
- Volume
- 39
- Issue
- 1
- Pages
- 61-78
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- PMC
- PMC3219414
- OpenAlex
- W2049630090
- Cited by
- 263
- References
- 222
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 11 · 2021: 19 · 2020: 23 · 2019: 23 · 2018: 20 · 2017: 19 · 2016: 21 · 2015: 22 · 2014: 23 · 2013: 12 · 2012: 11
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Office of Research and Development (2R01CA081595, 2R01MH62482)
- National Institutes of Health (5k24da016388-10)
- National Heart, Lung, and Blood Institute (R01HL072390, HL61784, HL72390, R01HL061784)
- National Institute of Mental Health (2R01MH62482, R01MH062482)
- National Institute on Drug Abuse (K24-DA-016388, 2K24DA016388)
- National Cancer Institute (R01CA081595)
- NIH Clinical Center
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, cardiovascular disease, metabolic disorders, cardiovascular risk factors, metabolic risk factors, biomarkers, socio-psychological factors, behavioral risk factors, PTSD assessment
- MeSH terms
- Cardiovascular Diseases, Depression, Hostility, Humans, Metabolic Diseases, Risk Factors, Stress Disorders, Post-Traumatic, Biomarkers, Evidence-Based Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
