Depression Treatment Enhances Adherence to Antiretroviral Therapy: a Meta-Analysis
Open accessAbstract
BACKGROUND: Depression is a risk factor for nonadherence to HIV/AIDS treatment. PURPOSE: A meta-analysis was conducted to examine whether treatment of depression and psychological distress improves antiretroviral therapy adherence. METHODS: PubMed and PsycINFO databases were systematically searched for relevant articles. Studies that reported an association between depression treatment (or an intervention with a component addressing mental health) and antiretroviral adherence were included. RESULTS: Across 29 studies of 12,243 persons living with HIV/AIDS, treatment of depression and psychological distress improved antiretroviral adherence (p < 0.001). The odds of a person adhering were 83 % better if he/she was treated for depression. Greater improvements in adherence were found for samples with lower CD4 counts or more severe depression, for interventions specifically targeting depression (versus addressing mental health as a secondary objective), longer treatments, and observational studies. CONCLUSIONS: These findings support the need for detection and treatment of depression among persons living with HIV/AIDS.
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In the presence of HIV, psychological treatments improve adherence to medical interventions as well as depression.
“importantly, improved adherence to medical interventions as well as improvement in depression.32”
From Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder (2016) · cites this paper as [32]
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References 64 · Cited by 266
- Authors
- Sin, N. L., & DiMatteo, M. R.
- Affiliations
- Pennsylvania State University (US)
- University of California, Riverside (US)
- Corresponding author
- Sin, Nancy L.
- ORCID
- Sin, Nancy L.
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11-14
- Volume
- 47
- Issue
- 3
- Pages
- 259-269
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- PMC
- PMC4021003
- OpenAlex
- W2150023922
- Semantic Scholar
- b2d2f3d12b5e1c8e648f29870feb4d37d517aa4b
- Cited by
- 266
- References
- 64
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 20 · 2023: 15 · 2022: 16 · 2021: 32 · 2020: 28 · 2019: 31 · 2018: 21 · 2017: 23 · 2016: 21 · 2015: 21 · 2014: 11 · 2013: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pennsylvania State University
- National Institute on Aging (T32AG000212, P30AG044281)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- depression treatment, antiretroviral therapy adherence, HIV/AIDS, psychological distress, mental health interventions, CD4 count, depression severity, treatment duration
- MeSH terms
- Antidepressive Agents, Depression, Female, Humans, Male, Psychotherapy, Stress, Psychological, HIV Infections, Treatment Outcome, Anti-Retroviral Agents, Medication Adherence
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