Ferroptosis is Involved in Acetaminophen Induced Cell Death

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Identification of RIP1 kinase as a specific cellular target of necrostatins

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ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

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Acetaminophen-Induced Hepatic Necrosis

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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

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Ferroptosis regulation by methylation in cancer

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A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

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Research progress on the mechanism of ferroptosis and its clinical application

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Ferroptosis: Environmental causes, biological redox signaling responses, cancer and other health consequences

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Ferroptosis as an emerging therapeutic target in liver diseases

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The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity

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Cell Death in Liver Disease and Liver Surgery

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Mechanistic elucidation of ferroptosis and ferritinophagy: implications for advancing our understanding of arthritis

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Protein S-glutathionylation confers cellular resistance to ferroptosis induced by glutathione depletion

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The Performance of HepG2 and HepaRG Systems through the Glass of Acetaminophen-Induced Toxicity

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Ferroptosis regulates key signaling pathways in gastrointestinal tumors: Underlying mechanisms and therapeutic strategies

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The Problem of Glutathione Determination: a Comparative Study on the Measurement of Glutathione from Plant Cells

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Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis

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Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

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Ferroptosis Biology and Implication in Cancers

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Linking homocysteine and ferroptosis in cardiovascular disease: insights and implications

Li, X., Zhou, Z., Tao, Y., He, L., Zhan, F., & Li, J. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01999-6 · Cited by 22

BPDE induces human trophoblast cell ferroptosis by up-regulating iron metabolism and promoting GPX4 proteasomal degradation

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Drug-induced oxidative stress actively prevents caspase activation and hepatocyte apoptosis

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Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond

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Mycobacterium tuberculosis infection induces a novel type of cell death: Ferroptosis

Wang, J., Cao, H., Xie, Y., Xu, Z., Li, Y., & Luo, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117030 · Cited by 18

Haem Oxygenase-1, Ferroptosis and Disorders—A Narrative Review

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Friend or Foe: The Relativity of (Anti)oxidative Agents and Pathways

Szarka, A., Lőrincz, T., & Hajdinák, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095188 · Cited by 18

The Regulation Role of Ferroptosis Mechanism of Anti-Cancer Drugs and Noncoding RNAs

Ensoy, M., Bumin, Z. S., Jama, H. A., & Cansaran‐Duman, D. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220629154418 · Cited by 17

Effect of ferroptosis inhibitors in a murine model of acetaminophen‐induced liver injury

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Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen

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GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure

Tao, J., Xue, C., Wang, X., Chen, H., Liu, Q., Jiang, C., & Zhang, W. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.85114 · Cited by 16

Deciphering ferroptosis in critical care: mechanisms, consequences, and therapeutic opportunities

Tan, R., Chen, G., Yan, Y., Guo, H., Han, X., Zhu, Q., & Du, Q. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1511015 · Cited by 15

Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes

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Potential applications of ferroptosis inducers and regulatory molecules in hematological malignancy therapy

Tang, X., Niu, Y., Jian, J., Guo, Y., Wang, Y., Zhu, Y. F., & Liu, B. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104203 · Cited by 15

Insights into the pathogenesis of gestational and hepatic diseases: the impact of ferroptosis

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Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma

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Unsupervised identification of disease states from high‐dimensional physiological and histopathological profiles

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Programmed cell death and melatonin: A comprehensive review

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Progress and Setbacks in Translating a Decade of Ferroptosis Research into Clinical Practice

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Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity

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Repurposing Niclosamide as a Therapeutic Drug against Acute Liver Failure by Suppressing Ferroptosis

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The Possible Connection of Two Dual Function Processes: The Relationship of Ferroptosis and the JNK Pathway

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Quantitative analysis of γ-glutamylpeptides by liquid chromatography-mass spectrometry and application for γ-glutamyltransferase assays

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GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin-induced myocardial injury mouse model

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A comprehension and systematic insight into the interaction between ferroptosis and virus infection: The implications of mechanisms and strategies

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Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways

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The role of hydrogen sulfide regulation of ferroptosis in different diseases

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Ferroptosis and its impact on common diseases

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7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression

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Nucleotide metabolism is linked to cysteine availability

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Basic mechanisms and novel potential therapeutic targets for ferroptosis in acute myeloid leukemia

Tang, X., Wang, Y., Zhu, Y., Guo, Y., & Liu, B. (2023) · Annals of Hematology · doi:10.1007/s00277-023-05293-4 · Cited by 13

Discovery of phenazine derivatives as a new class of non-classical ferroptosis inhibitors and efficacy evaluation on a mouse model of liver injury

Wu, Y., Lu, Y. Y., You, J., Tian, C., Yang, S., & Li, L. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117042 · Cited by 9

Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning

Guo, Z., Liu, J., Liang, G., Liang, H., Zhong, M., Tomlinson, S., He, S., Ouyang, G., & Yuan, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1371446 · Cited by 9

BGP-15 Protects Mitochondria in Acute, Acetaminophen Overdose Induced Liver Injury

Sarnyai, F., Szekerczés, T., Csala, M., Sümegi, B., Szarka, A., Schaff, Z., & Mandl, J. (2019) · Pathology & Oncology Research · doi:10.1007/s12253-019-00721-1 · Cited by 9

Ferroptosis: Molecular perspective, cellular influence, cancer manifestation, and therapeutic potentials

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The Ways to Die: Cell Death in Liver Pathophysiology

Cao, P., Jaeschke, H., Ni, H., & Ding, W. (2025) · Seminars in Liver Disease · doi:10.1055/a-2576-4332 · Cited by 11

An iron-deficient diet prevents alcohol- or diethylnitrosamine-induced acute hepatotoxicity in mice by inhibiting ferroptosis

Gao, Z., Wang, D., Zhang, H., Yang, J., Li, M., Lu, H., Shen, H., & Tang, Y. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.11.001 · Cited by 8

Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy

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Exploring the Updated Roles of Ferroptosis in Liver Diseases: Mechanisms, Regulators, and Therapeutic Implications

Ge, T., Wang, Y., Han, Y., Bao, X., & Chunfeng, L. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01611-3 · Cited by 7

Ferroptosis as a key player in the pathogenesis and intervention therapy in liver injury: focusing on drug-induced hepatotoxicity

Saeed, B. I., Uthirapathy, S., Kubaev, A., Ganesan, S., Shankhyan, A., Gupta, S., Joshi, K. K., Kariem, M., Jasim, A. S., & Ahmed, J. K. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04115-w · Cited by 7

The Therapeutic Effect of Natural Compounds on Osteoporosis through Ferroptosis

Zhang, Y., Qu, Z., Zhao, Y., Zhang, B., Gong, Y., Wang, X., Gao, X., Wang, D., & Yan, L. W. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673258420230919103405 · Cited by 9

Ferroptosis and its modulators: A raising target for cancer and Alzheimer’s disease

Singh, G., Kesharwani, P., Singh, G. K., Kumar, S., Putta, A., & Modi, G. P. (2023) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2023.117564 · Cited by 7

TFEB orchestrates ferritinophagy and ferroptosis in ionophore drug-induced hepatotoxicity: unveiling a novel therapeutic avenue

Wang, J., Song, X., Hui, Y., Dong, B., Gong, J., Zhao, Y., Ji, H., Qiu, Y., Jiang, S., Guo, D., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.05.401 · Cited by 6

Ferritinophagy-derived iron causes protein nitration and mitochondrial dysfunction in acetaminophen-induced liver injury

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Small Molecule Regulators of Ferroptosis

Debieu, S., Solier, S., Colombeau, L., Versini, A., Sindikubwabo, F., Forrester, A. R., Müller, S., Cañeque, T., & Rodriguez, R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-62026-4_6 · Cited by 6

Regulation of Ferroptosis Through the Cysteine-Glutathione Redox Axis

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Iron loading exerts synergistic action via a different mechanistic pathway from that of acetaminophen-induced hepatic injury in mice

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Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment

Shichiri, M., Suzuki, H., Isegawa, Y., & Tamai, H. (2022) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-61 · Cited by 6

Iron, copper and disulfide dysregulation: molecular crossroads of metabolic cell death in melanoma progression

Li, X., Gao, Y., Xing, Z., Liu, Z., & Zhang, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1685331 · Cited by 6

Deciphering Ferroptosis: From Molecular Pathways to Machine Learning-Guided Therapeutic Innovation

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Ferroptosis Resistance in Cancer: An Emerging Crisis of New Hope

Xu, D., Yonghui, L., Li, Y., Li, S., Wang, Z., & Wang, J. (2021) · BIO Integration · doi:10.15212/bioi-2020-0039 · Cited by 5

Emerging roles and therapeutic potentials of ferroptosis: from the perspective of 11 human body organ systems

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Therapeutic approach of glutathione/glutathione peroxidase-4 axis modulation in the light of ferroptosis

Georgiev, T., Hadzhibozheva, P., Karamalakova, Y. D., Georgieva, E., Perinkadakatt, F., Ilinov, Z., Petkov, K., & Ananiev, J. R. (2022) · Pharmacia · doi:10.3897/pharmacia.69.e87716 · Cited by 6

Sesamin alleviates drug-induced hepatotoxicity via autophagy enhancement and ferroptosis inhibition

Ren, J., Wang, Z., Zhang, Y., Pei, H., Wen, R., Zhang, Z., Zhu, S., Sun, X., Yin, B., Li, S., et al. (2025) · Redox Report · doi:10.1080/13510002.2025.2588863 · Cited by 4

Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury

Yang, D., Kim, B., & Kim, J.-W. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i45.112720 · Cited by 4

Ferroptosis: An emerging strategy for managing epithelial ovarian cancer

Alarcón-Veleiro, C., López-Calvo, I., Berjawi, L., Lucio-Gallego, S., Mato-Basalo, R., Varela, M. Q., Lesta-Mellid, R., Caínzos, I. S., Varela-Rodríguez, S., Fraga, M. F., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118065 · Cited by 6

Loss of BOK Has a Minor Impact on Acetaminophen Overdose-Induced Liver Damage in Mice

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Targeting both ferroptosis and pyroptosis may represent potential therapies for acute liver failure

Xing, Z.-Y., Zhang, C., & Liu, L.-J. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i33.3791 · Cited by 4

Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury

Liu, Y., Wang, Q., Xiangyang, Z.-Y., Long, J., Huang, H., & Fan, L. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00317-z · Cited by 3

Regulated necrosis at the crossroads of liver inflammation and cancer development

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The role of ferroptosis in the side effects of dexamethasone

Zhao, H., & Shang, H. (2022) · All Life · doi:10.1080/26895293.2022.2156623 · Cited by 3

Cell Injury and Necrosis

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Yeni Bir Hücre Ölüm Şekli Olarak Ferroptozis

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Ferroptosis in Liver Disease

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Ferroptosis and Radiotherapy in Lung Cancer

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Landscapes, highlights and trending topics of ferroptosis research in the liver: A bibliometric analysis

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In silico Analysis on the Possible Role of Mitochondria in Ferroptosis

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Loganin ameliorates acetaminophen-induced acute liver injury via targeting TOP1MT˗mediated hepatocyte apoptosis and ferroptosis

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Ferroptosis: Newly Emerged Regulator for Human Disease

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Nuclear DAMPs in Hepatic Injury and Inflammation

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Regulatory mechanism of ferroptosis, a new mode of cell death

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Targeting ferroptosis as a potential prevention and treatmentstrategy for human diseases

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Ferroptosis: Implications in Diseases and Potential Treatment Approaches

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Accumulation of polyunsaturated lipids fuels ferroptosis to promote liver failure after extended hepatectomy in mice

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Novel non-apoptotic cell death: ferroptosis

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Vízoldaható antioxidánsok döntéshelyzetben

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Recapitulating Parkinson’s disease pathology in a three-dimensional neural cell culture model

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Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

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Reactive oxygen species and peroxynitrite in acetaminophen-induced liver injury: Lipid peroxidation and ferroptosis-like cell death

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Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?

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Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression

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Oxidative Ferritin Destruction: A Key Mechanism of Iron Overload in Acetaminophen-Induced Hepatocyte Ferroptosis

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