Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer’s Disease
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To date, we still lack disease-modifying therapies for Alzheimer's disease (AD). Here, we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD. Five patients with mild to moderate AD received oral benfotiamine (300 mg daily) over 18 months. All patients were examined by positron emission tomography with Pittsburgh compound B (PiB-PET) and exhibited positive imaging with β-amyloid deposition, and three received PiB-PET imaging at follow-up. The five patients exhibited cognitive improvement as assayed by the Mini-Mental Status Examination (MMSE) with an average increase of 3.2 points at month 18 of benfotiamine administration. The three patients who received follow-up PiB-PET had a 36.7% increase in the average standardized uptake value ratio in the brain compared with that in the first scan. Importantly, the MMSE scores of these three had an average increase of 3 points during the same period. Benfotiamine significantly improved the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation. Our study provides new insight to the development of disease-modifying therapy.
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Administration of a synthetic thiamine derivative (300 mg/day for 18 months, orally) in five patients with mild to moderate dementia resulted in improved cognitive ability measured via the Mini-Mental State Examination.
“the administration of a synthetic derivative of thiamine (300 mg/day for 18 months, orally) in five patients with mild to moderate dementia resulted in improved cognitive ability measured via the Mini-Mental State Examination [196].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [196]
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References 25 · Cited by 59
- Authors
- Pan, X., Chen, Z., Fei, G., Pan, S., Bao, W., Ren, S., Guan, Y., & Zhong, C.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Corresponding author
- Zhong, Chunjiu
- Venue
- Neuroscience Bulletin
- Published
- 2016-10-01
- Volume
- 32
- Issue
- 6
- Pages
- 591-596
- ISSN
- 1995-8218 (ISSN-L)
- 1673-7067
- PMC
- PMC5567484
- OpenAlex
- W2524103117
- Cited by
- 59
- References
- 25
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 10 · 2017: 5
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China (81071019)
- Chinese Academy of Sciences
- Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- University of Toronto
- State Key Laboratory of Neuroscience
- Directorate for Biological Sciences
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- benfotiamine, Alzheimer's disease, cognitive enhancement, disease-modifying therapy, Pittsburgh compound B PET, amyloid-beta deposition, standardized uptake value ratio, Mini-Mental State Examination, long-term oral administration
- MeSH terms
- Adjuvants, Immunologic, Aged, Aged, 80 and over, Alzheimer Disease, Aniline Compounds, Chromatography, High Pressure Liquid, Cognition Disorders, Female, Humans, Longitudinal Studies, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Thiamine, Thiazoles, Positron-Emission Tomography
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