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A Review of the Functional and Anatomical Default Mode Network in Schizophrenia
Open accessAbstract
Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (DMN), since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.
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“a wealth of evidence links abnormalities in the corpus callosum and interhemispheric connectivity (driven by callosal projection neurons) to many neurodevelopmental disorders, among them ASD and SCZ2,3,111,112.”
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Metadata
- Authors
- Hu, M.-L., Zong, X.-F., Mann, J. J., Zheng, J.-J., Liao, Y.-H., Li, Z.-C., He, Y., Chen, X.-G., & Tang, J.-S.
- Affiliations
- New York State Psychiatric Institute (US)
- ORCID
- Mann, J. John
- Venue
- Neuroscience Bulletin
- Published
- 2016-12-19
- Volume
- 33
- Issue
- 1
- Pages
- 73-84
- ISSN
- 1995-8218 (ISSN-L)
- 1673-7067
- PMC
- PMC5567552
- OpenAlex
- W2565049982
- Cited by
- 331
- References
- 67
- Citations by year
- 2026: 20 · 2025: 48 · 2024: 43 · 2023: 46 · 2022: 47 · 2021: 38 · 2020: 36 · 2019: 27 · 2018: 19 · 2017: 6 · 2016: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (973 Program, 81271484, 30900486, 81471361, 81371480)
- China Scholarship Council (201506370095)
- National Key Research and Development Program of China (2012CB517904)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- default mode network, schizophrenia, functional connectivity, structural connectivity, task-positive network, heritability, antipsychotic drugs, treatment biomarkers, personalized treatment, brain network dysfunction
- MeSH terms
- Brain, Humans, Models, Neurological, Schizophrenia
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