The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Elastin in Large Artery Stiffness and Hypertension
Open accessAbstract
Large artery stiffness, as measured by pulse wave velocity, is correlated with high blood pressure and may be a causative factor in essential hypertension. The extracellular matrix components, specifically the mix of elastin and collagen in the vessel wall, determine the passive mechanical properties of the large arteries. Elastin is organized into elastic fibers in the wall during arterial development in a complex process that requires spatial and temporal coordination of numerous proteins. The elastic fibers last the lifetime of the organism but are subject to proteolytic degradation and chemical alterations that change their mechanical properties. This review discusses how alterations in the amount, assembly, organization, or chemical properties of the elastic fibers affect arterial stiffness and blood pressure. Strategies for encouraging or reversing alterations to the elastic fibers are addressed. Methods for determining the efficacy of these strategies, by measuring elastin amounts and arterial stiffness, are summarized. Therapies that have a direct effect on arterial stiffness through alterations to the elastic fibers in the wall may be an effective treatment for essential hypertension.
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Cites
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Cited by
The stiffness of living tissues and its implications for tissue engineering
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Age-related vascular stiffening: causes and consequences
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“Under physiological strain loads, the incremental elastic modulus is a function of strain and the combined contributions of elastin and collagen (Wagenseil and Mecham, 2012).”
Background
Metadata
- Authors
- Wagenseil, J. E., & Mecham, R. P.
- Venue
- Journal of Cardiovascular Translational Research
- Published
- 2012-01-31
- Volume
- 5
- Issue
- 3
- Pages
- 264-273
- ISSN
- 1937-5387 (ISSN-L)
- 1937-5395
- OpenAlex
- W2072411085
- Cited by
- 462
- References
- 87
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Wagenseil, J. E., & Mecham, R. P. (2012). Elastin in Large Artery Stiffness and Hypertension. Journal of Cardiovascular Translational Research. https://doi.org/10.1007/s12265-012-9349-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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