The Dynamics of Cardiovascular Biomarkers in non-Elite Marathon Runners
Open accessAbstract
The number of recreational/non-elite athletes participating in marathons is increasing, but data regarding impact of endurance exercise on cardiovascular health are conflicting. This study evaluated 79 recreational athletes of the 2016 Barcelona Marathon (72% men; mean age 39 ± 6 years; 71% ≥35 years). Blood samples were collected at baseline (24-48 h before the race), immediately after the race (1-2 h after the race), and 48-h post-race. Amino-terminal pro-B type natriuretic peptide (NT-proBNP, a marker of myocardial strain), ST2 (a marker of extracellular matrix remodeling and fibrosis, inflammation, and myocardial strain), and high-sensitivity troponin T (hs-TnT, a marker of myocyte stress/injury) were assayed. The median (interquartile range, IQR) years of training was 7 (5-11) years and median (IQR) weekly training hours was 6 (5-8) h/week, respectively. The median (IQR) race time (h:min:s) was 3:32:44 (3:18:50-3:51:46). Echocardiographic indices were within normal ranges. Immediately after the race, blood concentration of the three cardiac biomarkers increased significantly, with 1.3-, 1.6-, and 16-fold increases in NT-proBNP, ST2, and hs-TnT, respectively. We found an inverse relationship between weekly training hours and increased ST2 (p = 0.007), and a direct relationship between race time and increased hs-TnT (p < 0.001) and ST2 (p = 0.05). Our findings indicate that preparation for and participation in marathon running may affect multiple pathways affecting the car…
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Elite athletes may present higher levels of profibrotic markers which have been associated with incident or recurrent AF in the general population, including galectin-3, ST2, miR-21, TIMP-1, CITP, and PICP.
“Elite athletes may present higher levels of profibrotic markers which have been associated with incident or recurrent AF in the general population [66,67,68], including galectin-3 [69], the suppression of tumorigenicity 2 (ST2) [70], and microRNA-21 (miR-21) [71], as well as tissue inhibitors of metalloproteinase 1 (TIMP-1), C-terminal telopeptide of type I collagen (CITP), and procollagen type I”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [70]
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References 4 · Cited by 58
- Authors
- Roca, E., Nescolarde, L., Lupón, J., Barallat, J., Januzzi, J. L., Liu, P., Cruz Pastor, M., & Bayes-Genis, A.
- Affiliations
- Universitat Politècnica de Catalunya (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- Universitat Autònoma de Barcelona (ES)
- Massachusetts General Hospital (US)
- Ottawa Heart Institute (CA)
- Venue
- Journal of Cardiovascular Translational Research
- Published
- 2017-04
- Volume
- 10
- Issue
- 2
- Pages
- 206-208
- ISSN
- 1937-5387 (ISSN-L)
- 1937-5395
- OpenAlex
- W2604311185
- Cited by
- 58
- References
- 4
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 1
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- public-domain
- www.springer.com/tdm (unspecified)
- Locations
- Journal of Cardiovascular Translational Research (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, public-domain)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion, other-oa)
- UPCommons institutional repository (Universitat Politècnica de Catalunya) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- marathon running, endurance exercise, cardiac biomarkers, NT-proBNP, ST2, high-sensitivity troponin T, myocardial strain, myocardial injury, extracellular matrix remodeling, recreational athletes, race time, cardiovascular health
- MeSH terms
- Interleukin-1 Receptor-Like 1 Protein, Adaptation, Physiological, Adult, Cardiovascular System, Echocardiography, Female, Humans, Male, Middle Aged, Peptide Fragments, Physical Endurance, Running, Time Factors, Biomarkers, Natriuretic Peptide, Brain, Troponin T, Cardiomegaly, Exercise-Induced
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