CoChat
Sign Up
Cited by 37

The DOI matches its Crossref record.

Preparation, characterization, and pharmacokinetics of liposomal docetaxel for oral administration

Kim, Jung Ha, Shin, Dae Hwan, Kim, Jin-Seok·2018·Archives of Pharmacal Research
DOI 10.1007/s12272-018-1046-y
Open this paper in CoChat — free account

Abstract

A docetaxel (DTX) liposomal formulation composed of egg phosphatidylcholine, sodium deoxycholate, and stearylamine was developed. Eudragit (0.5%) was coated to deliver the drug to the region between the distal small intestine and the colon. Lyophilized trehalose and mannitol were used as cryoprotectants because they preserve the particle integrity and good appearance. In vitro release studies showed that the amount of drug released from the coated liposomes was low in solution 1, which simulated the pH condition of the stomach. Especially during the average gastric emptying time, the amount of drug released decreased when Eudragit was added. The plasma DTX concentration was evaluated in pharmacokinetic studies. The plasma drug concentration after intravenous (i.v.) administration decreased rapidly within 120 min. Free DTX formulated using Tween 80 and the lyophilized Eudragit-coated liposomal formulation were compared after oral administration. The oral liposomal formulation had a longer half-life (t 1/2 ) and three-fold higher oral bioavailability. Thus, lyophilized Eudragit-coated liposomal DTX could be a promising therapy for various solid tumors to improve patient convenience and quality of life.

Overview

Integrity signals

Registry

Crossref · 10.1007/s12272-018-1046-y

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 47

  1. Aungst BJ (1993) Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J Pharm Sci 82:979–987 · DOI
  2. Barea MJ, Jenkins MJ, Lee YS, Johnson P, Bridson RH (2012) Encapsulation of liposomes within pH responsive microspheres for oral colonic drug delivery. Int J Biomater 2012:458712 · DOI
  3. Cai Z, Wang Y, Zhu LJ, Liu ZQ (2010) Nanocarriers: a general strategy for enhancement of oral bioavailability of poorly absorbed or pre-systemically metabolized drugs. Curr Drug Metab 11:197–207 · DOI
  4. Chaudhury A, Das S, Lee RFS, Tan KB, Ng WK, Tan RBH, Chiu GNC (2012) Lyophilization of cholesterol-free PEGylated liposomes and its impact on drug loading by passive equilibration. Int J Pharm 430:167–175 · DOI
  5. Choi YH, Han H-K (2018) Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics. J Pharm Investig 48:43–60 · DOI
  6. Choi M, Shin DH, Kim J (2013) Repositioning of zoledronic acid for breast cancer using transferrin-conjugated liposome. J Pharm Investig 43:461–469 · DOI
  7. Clarke SJ, Rivory LP (1999) Clinical pharmacokinetics of docetaxel. Clin Pharmacokinet 36:99–114 · DOI
  8. DeMario MD, Ratain MJ (1998) Oral chemotherapy: rationale and future directions. J Clin Oncol 16:2557–2567 · DOI
  9. des Rieux A, Fievez V, Garinot M, Schneider YJ, Préat V (2006) Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J Control Release 116:1–27 · DOI · Paper page
  10. Engels F, Sparreboom A, Mathot R, Verweij J (2005) Potential for improvement of docetaxel-based chemotherapy: a pharmacological review. Br J Cancer 93:173–177 · DOI
  11. Esmaeili F, Dinarvand R, Ghahremani MH, Amini M, Rouhani H, Sepehri N, Ostad SN, Atyabi F (2008) Docetaxel–albumin conjugates: preparation, in vitro evaluation and biodistribution studies. J Pharm Sci 98:2718–2730 · DOI
  12. Fricker G, Kromp T, Wendel A, Blume A, Zirkel J, Rebmann H, Setzer C, Quinkert RO, Martin F, Müller-Goymann C (2010) Phospholipids and lipid-based formulations in oral drug delivery. Pharm Res 27:1469–1486 · DOI
  13. Gao K, Sun J, Liu K, Liu X, He Z (2008) Preparation and characterization of a submicron lipid emulsion of docetaxel: submicron lipid emulsion of docetaxel. Drug Dev Ind Pharm 34:1227–1237 · DOI
  14. Grosse P, Bressolle F, Pinguet F (1998) In vitro modulation of doxorubicin and docetaxel antitumoral activity by methyl-[beta]-cyclodextrin. Eur J Cancer 34:168–174 · DOI
  15. Guan T, Miao Y, Xu L, Yang S, Wang J, He H, Tang X, Cai C, Xu H (2011) Injectable nimodipine-loaded nanoliposomes: preparation, lyophilization and characteristics. Int J Pharm 410:180–187 · DOI
  16. Gulati M, Grover M, Singh S, Singh M (1998) Lipophilic drug derivatives in liposomes. Int J Pharm 165:129–168 · DOI
  17. Hua S (2014) Orally administered liposomal formulations for colon targeted drug delivery. Front Pharmacol 5:138
  18. Huizing M, Misser VHS, Pieters R, ten Bokkel Huinink W, Veenhof C, Vermorken J, Pinedo H, Beijnen J (1995) Taxanes: a new class of antitumor agents. Cancer Investig 13:381–404 · DOI
  19. Karn PR, Vanic Z, Pepic I, Skalko-Basnet N (2011) Mucoadhesive liposomal delivery systems: the choice of coating material. Drug Dev Ind Pharm 37:482–488 · DOI
  20. Kato Y, Hosokawa T, Hayakawa E, Ito K (1993) Influence of liposomes on tryptic digestion of insulin. Biol Pharm Bull 16:457–461 · DOI
  21. Khan MZI, Štedul HP, Kurjakovic N (2000) A pH-dependent colon-targeted oral drug delivery system using methacrylic acid copolymers. II. Manipulation of drug release using Eudragit® L100 and Eudragit S100 combinations. Drug Dev Ind Pharm 26:549–554 · DOI
  22. Khandare JJ, Jayant S, Singh A, Chandna P, Wang Y, Vorsa N, Minko T (2006) Dendrimer versus linear conjugate: influence of polymeric architecture on the delivery and anticancer effect of paclitaxel. Bioconjug Chem 17:1464–1472 · DOI
  23. Kruijtzer C, Beijnen J, Schellens J (2002) Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview. Oncologist 7:516–530 · DOI
  24. Kuppens I, Bosch T, Van Maanen M, Rosing H, Fitzpatrick A, Beijnen J, Schellens J (2005) Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093). Cancer Chemother Pharmacol 55:72–78 · DOI
  25. Lasic DD (1998) Novel applications of liposomes. Trends Biotechnol 16:307–321 · DOI
  26. Lee SH, Yoo SD, Lee KH (1999) Rapid and sensitive determination of paclitaxel in mouse plasma by high-performance liquid chromatography. J Chromatogr B 724:357–363 · DOI
  27. Liu J, Zahedi P, Zeng F, Allen C (2007) Nano-sized assemblies of a PEG-docetaxel conjugate as a formulation strategy for docetaxel. J Pharm Sci 97:3274–3290 · DOI
  28. Lyseng-Williamson KA, Fenton C (2005) Docetaxel: a review of its use in metastatic breast cancer. Drugs 65:2513–2531 · DOI
  29. Ma X, Williams RO (2018) Polymeric nanomedicines for poorly soluble drugs in oral delivery systems: an update. J Pharm Investig 48:61–75 · DOI
  30. Marchettini P, Stuart AO, Mohamed F, Yoo D, Sugarbaker PH (2002) Docetaxel: pharmacokinetics and tissue levels after intraperitoneal and intravenous administration in a rat model. Cancer Chemother Pharm 49:499–503 · DOI
  31. Nounou MM, El-Khordagui L, Khalafallah N, Khalil S (2005) Influence of different sugar cryoprotectants on the stability and physico-chemical characteristics of freeze-dried 5-fluorouracil plurilamellar vesicles. DARU J Pharm Sci 13:133–142
  32. Okabe T, Terashima H, Sakamoto A (2015) Determinants of liquid gastric emptying: comparisons between milk and isocalorically adjusted clear fluids. Br J Anaesth 114:77–82 · DOI
  33. O’Sullivan GM, Sutton AJ, Thompson SA, Carrie LE, Bullingham RE (1987) Noninvasive measurement of gastric emptying in obstetric patients. Anesth Analg 66:505–511 · DOI
  34. Patist A, Zoerb H (2005) Preservation mechanisms of trehalose in food and biosystems. Colloid Surf B 40:107–113 · DOI
  35. Ringel I, Horwitz SB (1991) Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol. J Natl Cancer Inst 83:288–291 · DOI
  36. Rouini M, Lotfolahi A, Stewart D, Molepo J, Shirazi F, Vergniol J, Tomiak E, Delorme F, Vernillet L, Giguere M (1998) A rapid reversed phase high performance liquid chromatographic method for the determination of docetaxel (Taxotere®) in human plasma using a column switching technique. J Pharm Biomed Anal 17:1243–1247 · DOI
  37. Rowinsky MEK (1997) The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu Rev Med 48:353–374 · DOI
  38. Russell-Jones G (2001) The potential use of receptor-mediated endocytosis for oral drug delivery. Adv Drug Deliv Rev 46:59–73 · DOI
  39. Schiff PB, Fant J, Horwitz SB (1979) Promotion of microtubule assembly in vitro by taxol. Nature 277:665–667 · DOI · Paper page
  40. Shin DH, Xuan S, Kim WY, Bae GU, Kim JS (2014) CD133 antibody-conjugated immunoliposomes encapsulating gemcitabine for targeting glioblastoma stem cells. J Mater Chem B 2:3707–3898 · DOI
  41. Sinha V, Singh A, Kumar RV, Singh S, Kumria R, Bhinge J (2007) Oral colon-specific drug delivery of protein and peptide drugs. Crit Rev Ther Drug Carrier Syst 24:63 · DOI
  42. Telang C, Yu L, Suryanarayanan R (2003) Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride. Pharm Res 20:660–667 · DOI
  43. van Winden ECA, Zhang W, Crommelin DJA (1997) Effect of freezing rate on the stability of liposomes during freeze-drying and rehydration. Pharm Res 14:1151–1160 · DOI
  44. Voskuhl J, Ravoo BJ (2008) Molecular recognition of bilayer vesicles. Chem Soc Rev 38:495–505 · DOI
  45. Weiss RB, Donehower R, Wiernik P, Ohnuma T, Gralla R, Trump D, Baker J Jr, Van Echo D, Von Hoff D, Leyland-Jones B (1990) Hypersensitivity reactions from taxol. J Clin Oncol 8:1263–1268 · DOI
  46. Wils P, Phung-Ba V, Warnery A, Lechardeur D, Raeissi S, Hidalgo IJ, Scherman D (1994) Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers. Biochem Pharmacol 48:1528–1530 · DOI
  47. Yin YM, Cui FD, Mu CF, Choi MK, Kim JS, Chung SJ, Shim CK, Kim DD (2009) Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation. J Control Release 140:86–94 · DOI

Cited by

Sorted by citations

Metadata

Authors
Kim, J. H., Shin, D. H., & Kim, J.-S.
Venue
Archives of Pharmacal Research
Publisher
Springer Science and Business Media LLC
Published
2018-06-30
Volume
41
Issue
7
Pages
765-775
ISSN
  • 0253-6269
  • 1976-3786
DOI
10.1007/s12272-018-1046-y
Cited by
37
References
0
Language
en
Licence
www.springer.com/tdm (tdm)
Funders
National Research Foundation of Korea (2017R1D1A1B03030849, 2011-0030074)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review