TSH Comparison Between Chemiluminescence (Architect) and Electrochemiluminescence (Cobas) Immunoassays: An Indian Population Perspective
Open accessAbstract
Although 3rd generation TSH assays are the most widely used immunoassays, credible comparison studies, specially involving Indian sub-populations are practically non-existent. To compare the TSH measurements between chemiluminescence (Architect) and electrochemiluminescence (Cobas) inmmunoassays in an urban ambulatory Indian population. 1,615 subjects were selected randomly from the usual laboratory workflow, their TSH measured in Architect and Cobas and the paired data thus generated were statistically analysed. TSH values of Cobas were observed to be higher than the Architect values by 28.7 %, with a significant proportional difference between the two, but majority of the Cobas values (above 90 %) were within the limits of agreement with Architect values. In situations where both the instruments are in use simultaneously, a standardization of the methods is imperative, in larger interest of the patient populace.
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State-of-the-art APS can be derived from evaluation and comparison of laboratory methods or from peer comparison data from proficiency testing programs.
“Alternatively, the state-of-the-art APS can be derived from the evaluation and comparison of laboratory methods99–104 or using peer comparison data from proficiency testing programs.105–107”
From Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status (2023) · cites this paper as [99]
The Introduction (page unavailable) identifies this as a study of the comparability of two laboratory methods, so it supports the method-comparison part of the citing sentence. Neither that passage nor the Discussion passages say that state-of-the-art analytical performance specifications can be derived from such comparisons. The proficiency-testing clause has separate citations and is not attributed to this paper. (LLM, conf=0.82)
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References 28 · Cited by 34
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- Pierce JG. The subunits of pituitary thyrotropin. Their relation- ship with other glycoprotein hormones. Endocrinology. 1971;89: 1331-44.
- C ¸ımrın D, S ¸is ¸man AR, Kenesarı Y, Ku ¨me T, Akan P, Cocer C. Comparison of Siemens Immulite and Abbott Architect TSH measurement methods. Turk Klinik Biyokimya Dergisi. 2011;9(3):97-103.
- Passing H, Bablok W, Bender R, Schneider B. A general regression procedure for method transformation. J Clin Chem Clin Biochem. 1988;26(11):783-90.
- Hendriks HA, Kortlandt W, Verweij WM. Analytical perfor- mance comparison of five new generation immunoassay analyz- ers. Ned Tijdschr Klin Chem. 2000;25:170-7.
- Bjerner J, Nustad K, Norum LF, Olsen KH, Børmer OP. Immu- nometric assay interferences: incidence and prevention. Clin Chem. 2002;48:613.
- Valdes R Jr, Miller TI. Increasing the specificity of immunoas- says. J Clin Immunoassay. 1992;15:87.
- Authors
- Sarkar, R.
- Corresponding author
- Sarkar, Rajarshi
- ORCID
- Sarkar, Rajarshi
- Venue
- Indian Journal of Clinical Biochemistry
- Published
- 2013-05-26
- Volume
- 29
- Issue
- 2
- Pages
- 189-195
- ISSN
- 0970-1915 (ISSN-L)
- 0974-0422
- PMC
- PMC3990813
- OpenAlex
- W2092463391
- Cited by
- 34
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 9 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 2
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Indian Journal of Clinical Biochemistry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
- Keywords
- thyroid-stimulating hormone, TSH immunoassay, chemiluminescence immunoassay, electrochemiluminescence immunoassay, architects, Coba, assay comparison, method standardization, Indian population
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