Lead and neurotoxicity
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Lead acts as a calcium mimetic, interfering with Ca2+-dependent signaling, compromising synaptic transmission fidelity, and disrupting early neurodevelopment.
“Lead poses a particular risk because it can act as a calcium mimetic, thereby interfering with Ca2+-dependent signaling pathways, compromising the fidelity of synaptic transmission, and severely disrupting early neurodevelopment (Florea et al., 2013; Sharma et al., 2015).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Sharma et al., 2015
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Research works printed but not linked: 7
- Ziegler EE, Edwards BB, Jensen RL, Mahaffey KR, Fomon SJ. Absorption and retention of lead by infants. Pediatr Res. 1978;12:29-34.
- Bellinger DC. The protean toxicities of lead: new chapters in a familiar story. Int J Environ Res Public Health. 2011;8:2593-628.
- Miranda ML, Kim D, Galeano MA, Paul CJ, Hull AP, Morgan SP. The relationship between early childhood blood lead levels and performance on end-of-grade tests. Environ Health Perspect. 2007;115:1242-7.
- Roy A, Bellinger D, Hu H, Schwartz J, Ettinger AS, Wright RO, et al. Lead exposure and behavior among young children in Chennai, India. Environ Health Perspect. 2009;117:1607-11.
- Khan DA, Qayyum S, Saleem S, Khan FA. Lead-induced oxi- dative stress adversely affects health of the occupational workers. Toxicol Ind Health. 2008;24:611-8.
- Sanders T, Liu Y, Buchner V, Tchounwou PB. Neurotoxic effects and biomarkers of lead exposure: a review. Rev Environ Health. 2009;24:15-45.
- Rajan P, Kelsey KT, Schwartz JD, Bellinger DC, Weuve J, Spiro A, et al. Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study. J Occup Environ Med. 2008;50:1053-61.
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S. Yousef, A. O., A. Fahad, A., Abdel Moneim, A. E., Metwally, D. M., El-khadragy, M. F., & Kassab, R. B. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16162895 · Cited by 110 · see citing works
Jocsak, G., Kiss, D. S., Alymbaeva, D., Diebald, A., Zsarnovszky, A., Heinzlmann, A., & Bartha, T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1821381 · Cited by 1 · see citing works
“Lead poses a particular risk because it can act as a calcium mimetic, thereby interfering with Ca 2+ -dependent signaling pathways, compromising the fidelity of synaptic transmission, and severely disrupting early neuro-development (Florea et al., 2013; Sharma et al., 2015).”
- Authors
- Sharma, P., Chambial, S., & Shukla, K. K.
- Affiliations
- All India Institute of Medical Sciences Jodhpur (IN)
- Corresponding author
- Sharma, Praveen
- Venue
- Indian Journal of Clinical Biochemistry
- Published
- 2015-01
- Volume
- 30
- Issue
- 1
- Pages
- 1-2
- ISSN
- 0970-1915 (ISSN-L)
- 0974-0422
- PMC
- PMC4310833
- OpenAlex
- W2023690927
- Cited by
- 76
- References
- 0
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 8 · 2020: 17 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Indian Journal of Clinical Biochemistry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- lead neurotoxicity, childhood lead exposure, blood lead levels, IQ decline, academic performance, attention deficit hyperactivity disorder, executive function, oxidative stress, lipid peroxidation, reactive oxygen species, metallothionein, metallochaperone, lead chelation
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