Depressive Symptoms and C-Reactive Protein Are Not Associated in a Population-Based Sample of Adolescents
Abstract
Background One potential mechanism to explain the association of depression and cardiovascular mortality is through increased inflammation. Adolescents typically have high levels of depressive symptoms, but the association of depression and levels of inflammation has not been examined within this age group.Purpose The objective was to study the association between high-sensitivity C-reactive protein (hs-CRP) concentrations and depressive symptoms in youth.Method Data were available for 1,535 adolescents aged 13 and 16 years obtained in a province-wide survey of a representative sample of youth in Quebec, Canada in 1999. Data on depressive symptoms were collected in self-report questionnaires. Participants provided a fasting blood sample, and anthropometric measures were undertaken by trained technicians.Results For each unit increase in the depression score, the odds ratio for elevated hs-CRP (i.e., > or =90th percentile value of the age- and sex-specific CRP distribution) was 1.06 (95% confidence interval 0.79, 1.42) after adjustment for age, sex, ever smoked, language, body mass index, physical inactivity, use of medication, total cholesterol concentration, triglycerides concentration, and systolic blood pressure.Conclusion These data do not support an association between depressive symptoms and elevated CRP in adolescents.
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In 1535 adolescents aged 13-16 years, no association between CRP levels and depressive symptoms was found.
“A cross-sectional study recruiting 1535 adolescents aged 13–16 years from a province-wide youth survey, did not find any association between CRP levels and depressive symptoms [49].”
From C-Reactive protein as a biomarker for major depressive disorder? (2022) · cites this paper as [49]
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References 34 · Cited by 29
- Authors
- Chaiton, M., O’Loughlin, J., Karp, I., & Lambert, M.
- Affiliations
- University of Toronto (CA)
- Institut National de Santé Publique du Québec (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Chaiton, Michael
- Venue
- International Journal of Behavioral Medicine
- Published
- 2010-02-24
- Volume
- 17
- Issue
- 3
- Pages
- 216-222
- ISSN
- 1070-5503 (ISSN-L)
- 1532-7558
- OpenAlex
- W1992628789
- Cited by
- 29
- References
- 34
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 2 · 2015: 3 · 2014: 1 · 2013: 2
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- depressive symptoms, C-reactive protein, inflammation, adolescents, high-sensitivity CRP, adolescent mental health
- MeSH terms
- Adolescent, Age Factors, Blood Pressure, C-Reactive Protein, Cholesterol, Depression, Female, Humans, Male, Motor Activity, Sex Factors, Triglycerides, Body Mass Index, Confidence Intervals, Odds Ratio
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