The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Renin–angiotensin system research: from molecules to the whole body
Open accessAbstract
Hypertension is one of the most important risk factors and a leading cause of death from cardiovascular and cerebrovascular diseases. Based on numerous previous studies, hypertension is thought to be caused by the complex mutual interactions of genetic factors and environmental factors, such as excessive salt intake and stress. However, its detailed mechanisms are not yet clearly understood. The renin-angiotensin system (RAS) is a key hormonal system in the pathogenesis of hypertension. New knowledge is still accruing on this cascade, even after more than 120 years since the discovery of renin. To clarify the molecular mechanisms of RAS in vivo, we created transgenic mice with chronic hypertension. These mice carry the human genes encoding renin, a hypertensive enzyme, and its substrate angiotensinogen. Hypotensive mice homozygous for a targeted disruption of the angiotensinogen gene were also created. This review presents our 47-year history of RAS research.
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In the citing paper
“Up till now, two key polypeptides in RAS as well as their enzymes and receptors constitute two core pathways in this system, ACE-Ang II-AT1/2R and ACE2-Ang(1–7)-MasR, which restrict each other and jointly maintain the relative stability of the internal environment [28–30].”
In the citing paper
“In particular, we should not ignore the counteracting effect of Ang(1–7) on the overactivated Ang II axis [28–30].”
Citations
Cites
Arzneimittelforschung: Erstanwendung am Menschen in der Phase I
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401
Global Brief on Hypertension: Silent Killer, Global Public Health Crisis
Haldar, R. (2013) · Indian Journal of Physical Medicine and Rehabilitation · doi:10.5005/ijopmr-24-1-2 · Cited by 914
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
Ichiki, T., Labosky, P. A., Shiota, C., Okuyama, S., Imagawa, Y., Fogo, A., Niimura, F., Ichikawa, I., Hogan, B. L. M., & lnagami, T. (1995) · Nature · doi:10.1038/377748a0 · Cited by 855
The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition
Atlas, S. A. (2007) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2007.13.s8-b.9 · Cited by 722
Male–female differences in fertility and blood pressure in ACE-deficient mice
Krege, J. H., John, S. W. M., Langenbach, L. L., Hodgin, J. B., Hagaman, J. R., Bachman, E. S., Jennette, J. C., O’Brien, D. A., & Smithies, O. (1995) · Nature · doi:10.1038/375146a0 · Cited by 646
Regulation of blood pressure by the type 1A angiotensin II receptor gene.
Ito, M., Oliverio, M. I., Mannon, P. J., Best, C. F., Maeda, N., Smithies, O., & Coffman, T. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.8.3521 · Cited by 616
Esther, C. R., Howard, T. E., Marino, E. M., Goddard, J. M., Capecchi, M. R., & Bernstein, K. E. (1996) · PubMed · Cited by 440
Angiotensinogen-deficient mice with hypotension.
Tanimoto, K., Sugiyama, F., Goto, Y., Ishida, J., Takimoto, E., Yagami, K.-I., Fukamizu, A., & Murakami, K. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31697-1 · Cited by 369
Self-citationAngiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia
Sugaya, T., Nishimatsu, S., Tanimoto, K., Takimoto, E., Yamagishi, T., IMAMURA, K., Goto, S., Imaizumi, K., Hisada, Y., Otsuka, A., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18719 · Cited by 358
Self-citationWithin the Brain: The Renin Angiotensin System
Jackson, L., Eldahshan, W., Fagan, S., & Ergul, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030876 · Cited by 336
Cited by
Wei, L., Bo, L., Luo, C., Yin, N., Jiang, W., Qian, F., Zhou, A., Lu, X., Guo, H., & Mao, C. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03997-6 · Cited by 11
“In particular, we should not ignore the counteracting effect of Ang(1–7) on the overactivated Ang II axis [28–30].”
Background
Metadata
- Authors
- Takimoto-Ohnishi, E., & Murakami, K.
- Affiliations
- Foundation for Advancement of International Science (JP)
- Corresponding author
- Murakami, Kazuo
- ORCID
- Murakami, Kazuo
- Venue
- The Journal of Physiological Sciences
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 69
- Issue
- 4
- Pages
- 581-587
- ISSN
- 1880-6546 (ISSN-L)
- PMC
- PMC10717639
- OpenAlex
- W2940798203
- Cited by
- 62
- References
- 33
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 12 · 2023: 11 · 2022: 7 · 2021: 8 · 2020: 11
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 2011 d)
- Locations
- The Journal of Physiological Sciences (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fumi Yamamura Memorial Foundation for Female Natural Scientists
- Inamori Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- University of Tsukuba
- Kanae Foundation for the Promotion of Medical Science
- Nissan Global Foundation
- Japan Society for the Promotion of Science (17H02171)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Keywords
- renin-angiotensin system, hypertension, angiotensinogen, renin, transgenic mice, salt intake, stress, cardiovascular disease, cerebrovascular disease, genetic and environmental risk factors
- MeSH terms
- Angiotensinogen, Animals, Humans, Hypertension, Renin-Angiotensin System
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- CoChat. (2026). Citation check: Renin–angiotensin system research: from molecules to the whole body. https://app.cochat.ai/papers/10.1007/s12576-019-00679-4
- The paper
- Takimoto-Ohnishi, E., & Murakami, K. (2019). Renin–angiotensin system research: from molecules to the whole body. The Journal of Physiological Sciences. https://doi.org/10.1007/s12576-019-00679-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
