Naturally Occurring Antibodies to Tau Exists in Human Blood and Are Not Changed in Alzheimer’s Disease
Abstract
Hyperphosphorylated tau is an important pathological agent in Alzheimer's disease (AD). Tau effluxes from the brain to the blood could potentially stimulate the production of naturally occurring antibodies (NAbs). We aimed to investigate whether NAbs to tau (NAbs-tau) was generated in human blood and to figure out the alteration of plasma NAbs-tau level in AD patients. About 192 AD patients and 192 age-matched and non-demented controls (NC) were enrolled in the present study. Immunofluorescence staining and western blot assays were used to confirm the existence of NAbs-tau in human blood. The plasma level of NAbs-tau in NC and AD group was analyzed by ELISA. Immunofluorescence staining and western blot assays confirmed the existence of NAbs-tau in human blood. However, no significant difference in the plasma level of NAbs-tau was observed between NC and AD group. Furthermore, the plasma level of NAbs-tau had no significant correlation with MMSE scores. The present study confirmed that NAbs-tau exists in human blood but does not differ in level between the NC and AD group. Plasma NAbs-tau is not a reliable biomarker for AD.
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Naturally occurring anti-tau antibodies are detected in both AD patients and healthy controls without significant inter-group differences in their levels or correlation with cognitive decline.
“naturally occurring anti-tau antibodies are detected in both AD patients and healthy controls without significant inter-group differences in their levels or correlation with cognitive decline”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [103]
Cites
Castillo-Carranza, D. L., Sengupta, U., Guerrero-Muñoz, M. J., Lasagna-Reeves, C. A., Gerson, J. E., Singh, G., Estes, D. M., Barrett, A. D. T., Dineley, K. T., Jackson, G. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3192-13.2014 · Cited by 278 · cited 3× · see citing works
“The latter is the main component of neurofibrillary tangles (NFTs) (Avila et al. 2016; Castillo-Carranza et al. 2014), which may spread throughout the cortex by interneural tau transfer and is reported to accelerate the pathogenesis of AD (Nobuhara et al.”
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Is there a role for B cells in Alzheimer's disease?
Charavner, E.-L., Fillatreau, S., & El Behi, M. (2026) · Cellular Immunology · doi:10.1016/j.cellimm.2026.105154
- Authors
- Yu, Z.-Y., Li, W.-W., Yang, H.-M., Mañucat-Tan, N. B., Wang, J., Wang, Y.-R., Sun, B.-L., Hu, Z.-C., Zhang, L.-L., Tan, L., Deng, J., & Liu, Y.-H.
- Affiliations
- Army Medical University (CN)
- Corresponding author
- Deng, Juan
- Venue
- Neurotoxicity Research
- Published
- 2020-02-05
- Volume
- 37
- Issue
- 4
- Pages
- 1029-1035
- ISSN
- 1029-8428 (ISSN-L)
- 1476-3524
- OpenAlex
- W3005428899
- Cited by
- 9
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 3 · 2021: 2 · 2020: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurotoxicity Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81600936, 81671277)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- natural antibodies, tau protein, Alzheimer's disease, hyperphosphorylated tau, plasma biomarkers, blood antibodies
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Animals, Autoantibodies, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Middle Aged, Biomarkers, tau Proteins, Mice
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