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Hyaluronic acid production by utilizing agro-industrial waste cane molasses
Open accessAbstract
Hyaluronic acid is a polysaccharide endowed with distinctive biological and physiological competencies. Given its queer properties, hyaluronic acid has exclusive praxis in the cosmetics and medical industries. The surmounting demand for hyaluronic acid is the propulsion behind the necessity for finding the amenable ways for its production. Fermentation progression of Streptococcus zooepidemicus is reckoned as the superlative prompt and ambient approach for hyaluronic acid fabrication. For the unabated advancements in the industrial production of hyaluronan, industrial byproducts utilization is a fateful stile. The recent perusal is to optimize the fermentation production conditions of hyaluronic acid using cane molasses (a byproduct of sugar production) as a carbon source. The impact of different ranges of temperatures (33-41 °C), pH (6-8), and agitation rates (100-250 rpm) on the production process was calibrated using RSM using CCD as a statistical modality. In a 3.7 L bioreactor, 3.31 g/L hyaluronic acid was achieved at 9.74 percent molasses, 36.2 °C, pH 6.46, and a 207 rpm agitation rate using a batch fermentation technique. With a pH of 7, HPLC was conducted at 25 °C using a C18 column at a rate of 0.8 ml/min, and the wavelength was determined using a UV detector. The average retention time was 2.202 min. The FT-IR spectrum's output was also observed, and it matched the standard hyaluronic acid well.
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“Agro-industrial waste cane molasses Streptococcus zooepidemicus MTCC 3523 Moisturizing, anti-aging [165]”
From Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review (2024) · cites this paper as [165]
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Cited by
Sorted by citations
Krzyżostan, M., Wawrzyńczak, A., & Nowak, I. (2024) · Sustainability · doi:10.3390/su16072757 · Cited by 47
“The main pillars of the Green Deal which apply to the cosmetics industry are circular economy and zero pollutions, which means reduction in the greenhouse gas emission, assurance of resource efficiency in a circular economy, the protection and restoration of ecosystems, and biodiversity.”
Metadata
- Authors
- Shukla, P., Anand, S., Srivastava, P., & Mishra, A.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Corresponding author
- Mishra, Abha
- Venue
- 3 Biotech
- Published
- 2022-08-04
- Volume
- 12
- Issue
- 9
- Pages
- 208-208
- ISSN
- 2190-572X (ISSN-L)
- 2190-5738
- PMC
- PMC9352846
- OpenAlex
- W4289730942
- Cited by
- 16
- References
- 47
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 4
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- 3 Biotech (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Keywords
- hyaluronic acid, Streptococcus zooepidemicus, sugarcane molasses, agro-industrial waste, fermentation optimization, response surface methodology, batch fermentation, carbon source, pH and temperature effects, stirring speed
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