The emerging role of Nemo-like kinase (NLK) in the regulation of cancers
Abstract
Nemo-like kinase (NLK) is an evolutionarily conserved mitogen-activated protein (MAP) kinase-related kinase that is highly expressed in neural tissues and minimally detected in others. Accumulating evidence demonstrates that NLK exerts a pivotal role in cell proliferation, migration, invasion, and apoptosis via regulation of a variety of transcriptional molecules. The results of recent studies have shown that aberrant expression of NLK is significantly associated with the initiation and progression of various types of human cancers, as well as clinicopathologic features and survival rate. NLK is gradually considered as a potential tumor suppressor or an oncogene depending on the tumor system, and silencing or upregulating of NLK may provide an effective therapeutic approach against tumors. In this review, we will make a summary on the comprehensive roles of NLK in the regulation of various cancers.
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Dysregulation in NLK expression can affect the development and progression of various diseases, including cancer, where NLK acts as a tumour suppressor or oncogene depending on the tumour type.
“In addition, dysregulation in NLK expression can affect the development and progression of various diseases, including cancer, where NLK has been found to act as a tumour suppressor or oncogene depending on the tumour type [27].”
From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [27]
Cites
Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene
Choi, K.-W., & Benzer, S. (1994) · Cell · doi:10.1016/0092-8674(94)90579-7 · Cited by 339 · see citing works
Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1379-1389.2003 · Cited by 212 · see citing works
YASUDA, J., & ICHIKAWA, H. (2007) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.83.16 · Cited by 6 · see citing works
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Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies
Daams, R., & Massoumi, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239203 · Cited by 21 · see citing works
“In addition, dysregulation in NLK expression can affect the development and progression of various diseases, including cancer, where NLK has been found to act as a tumour suppressor or oncogene depending on the tumour type [27].”
Background
- Authors
- Huang, Y., Yang, Y., He, Y., & Li, J.
- Affiliations
- Anhui Medical University (CN)
- Venue
- Tumor Biology
- Published
- 2015-10-01
- Volume
- 36
- Issue
- 12
- Pages
- 9147-9152
- ISSN
- 1010-4283 (ISSN-L)
- 1423-0380
- OpenAlex
- W1834098278
- Cited by
- 19
- References
- 3
- Citations by year
- 2024: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 4 · 2016: 1
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Tumor Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- Nemo-like kinase, cancer, tumor suppressor, oncogenes, cell proliferation, cell migration, tumor invasion, apoptosis, transcriptional regulation, therapeutic target
- MeSH terms
- Humans, Neoplasms, Gene Expression Regulation, Neoplastic, Apoptosis, Protein Serine-Threonine Kinases, RNA, Untranslated, Intracellular Signaling Peptides and Proteins, Cell Proliferation, Wnt Signaling Pathway
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