Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
Open accessAbstract
Lysosomes are acidic, membrane-bound organelles that serve as the primary catabolic compartment of the cell. They are crucial to a variety of cellular processes from nutrient storage to autophagy. Given the diversity of lysosomal functions, it is unsurprising that lysosomes are also emerging as important players in aging. Lysosomal dysfunction is implicated in several aging-related neurodegenerative diseases including Alzheimer's, Parkinson's, amyotrophic lateral sclerosis/frontotemporal dementia, and Huntington's. Although the precise role of lysosomes in the aging brain is not well-elucidated, some insight into their function has been gained from our understanding of the pathophysiology of age-dependent neurodegenerative diseases. Therapeutic strategies targeting lysosomes and autophagic machinery have already been tested in several of these diseases with promising results, suggesting that improving lysosomal function could be similarly beneficial in preserving function in the aging brain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mutations in genes encoding MAPT, GRN, C9orf72, FUS, TDP-43, VCP, and CHMP2B are associated with defective autophagic clearance and lysosomal function in FTLD.
“These mutations are associated with defective autophagic clearance and lysosomal function.196”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [196]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 367 · Cited by 79
Part of this paper’s reference list could not be split into single entries.
Research works printed but not linked: 1
- Sugiura A, McLelland GL, Fon EA, McBride HM. A new path- way for mitochondrial quality control: mitochondrial-derived ves- icles. EMBO J 2014;33(19):2142-2156.
- Authors
- Peng, W., Minakaki, G., Nguyen, M., & Krainc, D.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Krainc, Dimitri
- Venue
- Neurotherapeutics
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 16
- Issue
- 3
- Pages
- 611-634
- ISSN
- 1878-7479 (ISSN-L)
- PMC
- PMC6694346
- OpenAlex
- W2950805610
- Cited by
- 79
- References
- 367
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 13 · 2020: 10 · 2019: 4
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-07-15)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurotherapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS076054, R37 NS096241)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- lysosomes, lysosomal dysfunction, brain aging, neurodegeneration, autophagy, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Huntington's disease
- MeSH terms
- Aging, Amyotrophic Lateral Sclerosis, Brain, Humans, Huntington Disease, Lysosomes, Mitochondria, Parkinson Disease, Neurodegenerative Diseases, Frontotemporal Dementia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
