A comprehensive review of SHP2 and its role in cancer

Asmamaw, Moges Dessale, Shi, Xiao-Jing, Zhang, Li-Rong, Liu, Hong-Min·2022·Cellular Oncology
DOI 10.1007/s13402-022-00698-1

Cited by (120)

Items 101–120 of 120

  1. Investigation of the non-ergodicity of protein dynamics
    Luca Maggi · 2026 · Physical Chemistry Chemical Physics
  2. Multi-omic profiling identifies distinct MAPK-centric subgroups in BRAF- and PTPN11-mutant IDH-wildtype glioblastoma
    Tim Vladimirov, László Bárány, Sebastian Jeising, Oliver Schnell, Daniel Delev, Dieter Henrik Heiland · 2026 · Research Square
  3. SHP2 in TAMs promoted the survival of gastric adenocarcinoma via suppressing the P38/ERK1/2/SP1/BRD4/STING induced inflammation and ROS
    Jing Bai, Hui Ren, Ye Zhang, Xiao Li · 2026 · Frontiers in Medicine
  4. Novel Benzothiazole Derivatives: Synthesis, Fluorescence Properties, Bioactivity for SHP2
    隽威 朱 · 2026 · Hans Journal of Medicinal Chemistry
  5. BGC1201: A potent allosteric SHP2 inhibitor with broad antitumor activity in lung, pancreatic, and esophageal cancer xenografts
    Yue Wang, Jiahui Xia, Haifeng Ding, Duxin Li · 2026 · Pharmaceutical Science Advances
  6. Muscle‐Specific Kinase Signaling and Its Therapeutic Potential
    Stine Marie Jensen, Dana L.E. Vergoossen, Maartje G. M. Huijbers · 2026 · Muscle & Nerve
  7. SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor
    Cen Zhao, Ihor Yakymovych, Mariya Yakymovych, Pengwei Xing, Carl‐Henrik Heldin · 2026 · Cell Communication and Signaling
  8. Biomarker-driven neoadjuvant immunotherapy in triple-negative breast cancer: emerging therapeutic targets FOXP3 and WT1
    Ziwei Zhang, Renjie Zhao, Yuan Hu, Qiyu Xie, Yan Yu, Kefan Li, Zhenyu Ding, Manni Wang · 2026 · Frontiers in Immunology
  9. Deciphering SHP-2 conformational switching via elastic network models and transfer entropy analysis
    Qinchen Si, Zhixiang Wu · 2026 · Journal of Molecular Modeling
  10. QinZhuLiangXue gel alleviates psoriasiform inflammation through immunomodulatory effects involving PD-1/PD-L1/SHP2 signaling axis
    Weixuan Yuan, Suting Sun, Tianyou Ma, Mengji Xie, Yu Huang, Le Kuai, Ying Luo, Jiankun Song, Xiaojie Ding, Yi Ru et al. · 2026 · Journal of Ethnopharmacology
  11. Fragment-Based Covalent Targeting of Lysines at the Allosteric Latch Site of SHP2
    V. di Lorenzo, Noémi Csorba, Renáta Szabó, Levente Kollár, Yvette Roske, Ivan Ranđelović, Krisztina Balázs, Tibor Viktor Szalai, Nina‐Louisa Efrém, Levente M. Mihalovits et al. · 2026 · Journal of Medicinal Chemistry
  12. RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses
    Zongda Li, Chengwei Zhang, Xinying Yu, Shuang Yao, Yiting Lai, Xiaozhu Sun, Yao Zhao, Xiaoyu Lan, Tingting Hu, Wenjin Li et al. · 2026 · Advanced Science
  13. Sequence space exploration in SHP2: mechanistic insights from disease-associated mutations
    Anne E. van Vlimmeren, Ziyuan Jiang, Devon A. Semoy, Neel H. Shah · 2026 · Biochemical Journal
  14. BindingDB Entry 50020372: Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.
    BindingDB · 2024 · UC San Diego
  15. BindingDB Entry 50023438: Covalent-Allosteric Inhibitors: Do We Get the Best of Both Worlds?
    BindingDB · 2026 · UC San Diego
  16. BindingDB Entry 50019054: Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
    BindingDB · 2024 · UC San Diego
  17. BindingDB Entry 50023566: Combination therapy and dual-target inhibitors based on cyclin-dependent kinases (CDKs): Emerging strategies for cancer therapy.
    BindingDB · 2026 · UC San Diego
  18. BindingDB Entry 50021202: Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human CDC14 Phosphatases.
    BindingDB · 2025 · UC San Diego
  19. BindingDB Entry 50022241: Discovery of novel substituted pyridine carboxamide derivatives as potent allosteric SHP2 inhibitors.
    BindingDB · 2025 · UC San Diego
  20. BindingDB Entry 50021399: Design, Synthesis and Antitumor Activity of a Novel Class of SHP2 Allosteric Inhibitors with a Furanyl Amide-Based Scaffold.
    BindingDB · 2025 · UC San Diego