Dietary cholesterol and plasma lipoprotein profiles: randomized-controlled trials
Open accessAbstract
Early work suggested that dietary cholesterol increases plasma total cholesterol concentrations in humans. Given the relationship between elevated plasma cholesterol concentrations and cardiovascular disease risk dietary guidelines have consistently recommended limiting food sources of cholesterol. Current intakes are approaching recommended levels. Recently there have been calls to reassess the importance of continuing to recommend limiting dietary cholesterol. Over the past 10 years there have been a limited number of studies addressing this issue. Striking among these studies is the high degree of variability in background diet, subject characteristics and study design. Within the context of current levels of dietary cholesterol intake, the effect on plasma lipids concentrations, with primary interest in LDL-C cholesterol concentrations, is modest and appears to be limited to population subgroups. In these cases, restrictions in dietary cholesterol intake are likely warranted. The biological determinants of inter-individual variability remain a relatively understudied area.
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Experimental studies in humans show marked variability among individuals in effects of dietary cholesterol on cholesterol absorption and lipid metabolism.
“Several experimental studies in humans have evaluated the effects of dietary cholesterol on cholesterol absorption and lipid metabolism and have revealed marked variability among individuals. 167,168”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [167]
Experimental studies in humans show marked variability among individuals in effects of dietary cholesterol on cholesterol absorption and lipid metabolism.
“Several experimental studies in humans have evaluated the effects of dietary cholesterol on cholesterol absorption and lipid metabolism and have revealed marked variability among individuals.167,168”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [167]
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References 38 · Cited by 64
Research works printed but not linked: 1
- [15]AHA Dietary Guidelines for Healthy American Adults Circulation 1986 74 1465A 1468A 3779925
- Authors
- Griffin, J. D., & Lichtenstein, A. H.
- Affiliations
- Tufts University (US)
- Corresponding author
- Lichtenstein, Alice H.
- Venue
- Current Nutrition Reports
- Published
- 2013-10-18
- Volume
- 2
- Issue
- 4
- Pages
- 274-282
- ISSN
- 2161-3311 (ISSN-L)
- PMC
- PMC3900007
- OpenAlex
- W1996116130
- Cited by
- 64
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Nutrition Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL074388)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK062032)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- dietary cholesterol, serum lipoproteins, LDL cholesterol, total cholesterol, cardiovascular risk, cholesterol intake, dietary guidelines, interindividual variability, randomized controlled trials
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