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Cited by 35Clostridium difficile and Clostridium perfringens researchInfection Control in HealthcareGeriatric Care and Nursing Homes

Clostridium difficile in the Long-Term Care Facility: Prevention and Management

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Jump, Robin L. P., Donskey, Curtis J.·2015·Current Geriatrics Reports
DOI 10.1007/s13670-014-0108-3PMC PMC4322371
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Abstract

Residents of long-term care facilities are at high risk for Clostridium difficile infection due to frequent antibiotic exposure in a population already rendered vulnerable to infection due to advanced age, multiple comorbid conditions and communal living conditions. Moreover, asymptomatic carriage of toxigenic C. difficile and recurrent infections are prevalent in this population. Here, we discuss epidemiology and management of C. difficile infection among residents of long-term care facilities. Also, recognizing that both the population and culture differs significantly from that of hospitals, we also address prevention strategies specific to LTCFs.

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  • Laxative use may disrupt gut microbiota and potentially increase susceptibility to Clostridium difficile infection.

    “Laxative use may disrupt gut microbiota and potentially increase susceptibility to Clostridium difficile infection (CDI) (18, 19).”

    From Effectiveness of Partially Hydrolyzed Guar Gum in Reducing Constipation in Long Term Care Facility Residents: A Randomized Single-Blinded Placebo-Controlled Trial (2022) · cites this paper as [19]

    The Microbiology & Pathogenesis section says a disrupted gut microbiome permits C. difficile to grow, supporting the proposed link between microbiome disruption and susceptibility. But it identifies systemic antimicrobials, not laxatives, as the common cause of disruption. The Diagnosis section mentions laxatives only as a noninfectious cause of diarrhea that can lead to inappropriate CDI testing; it does not say laxatives disrupt the microbiome. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Jump, R. L. P., & Donskey, C. J.
Affiliations
  • Case Western Reserve University (US)
  • Louis Stokes Cleveland VA Medical Center (US)
Corresponding author
Jump, Robin L. P.
ORCID
Venue
Current Geriatrics Reports
Publisher
Springer Science and Business Media LLC
Published
2014-10-19
Volume
4
Issue
1
Pages
60-69
ISSN
2196-7865 (ISSN-L)
DOI
10.1007/s13670-014-0108-3
PMC
PMC4322371
OpenAlex
W1985610050
Cited by
35
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 2
FWCI
1.08
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Geriatrics Reports (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (KL2TR000440, UL1TR000439)
  • National Institute on Aging (R03AG040722)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
  • Health Sciences › Health Professions › General Health Professions › Geriatric Care and Nursing Homes
Keywords
Clostridium difficile infection, long-term care facilities, infection control, asymptomatic carriage, recurrent infections, antibiotic exposure, older adults, infection management, nursing homes

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